手术切除的肝门部胆管癌生存危险因素分析  

Analysis of survival risk factor for porta hepatic cholangiocarcinoma with exairesis

作　　者：徐定银[1] 郭德超[1] 虞名旭[1] 宋胜江[1] 

机构地区：[1]温州医科大学附属第三医院普外科,浙江温州325200

出　　处：《肝胆胰外科杂志》2014年第1期16-19,共4页Journal of Hepatopancreatobiliary Surgery

摘　　要：目的 探讨肝门部胆管癌手术治疗后影响患者生存的危险因素.方法 对我院2002年1月至2012年1月126例手术切除的肝门部胆管癌患者的临床资料进行回顾性分析,采用Kaplan-Meier法分析患者中位生存时间,采用x2检验分析患者生存时间的相关因素,COX生存风险比例模型分析患者生存的危险因素.结果 手术切除的肝门部胆管癌患者术后生存时间为4 ～ 46个月,中位生存时间是19个月,分析结果显示,肿瘤分型、切除范围、切缘状况、门静脉浸润与否,白蛋白水平,间接胆红素水平与患者术后生存时间相关,其中肿瘤分型、切除范围、切缘状况、门静脉浸润与否是影响患者术后生存的独立危险因素.结论 肝门部胆管癌患者预后较差,患者肿瘤的进展程度及手术切除程度是影响患者预后生存的主要危险因素.Objective To explore the risk factors that affect survival of patients with porta hepatic cholangiocarcinoma excised. Methods One hundred and twewty-six cases of patients with cholangiocarcinoma excised in our hospital from Jan. 2002 to Jan. 2012 were selected and analyzed retrospectively, survival time were analyzed with Kaplan-Meier test, survival correlation factor were screened with monofactorial test, independent survival risk factor were analyzed with COX model. Results Survival time of patients with porta hepatic cholangiocarcinoma excised was 4 to 46 months, median survival time was 19 months, analysis showed that type of tumor, extent of excision, conditions of incisal margin, whether or not portal vein encroached, level of ALB and IBIL were correlated factors with postoperative survival duration, and the type of tumor, extent of excision, conditions of incisal margin, whether or not portal vein encroached were independent survival risk factors for patients with porta hepatic cholangiocarcinoma excised. Conclusion Porta hepatic cholangiocarcinoma have bad prognosis, progression degree and exairesis degree are the major risk factor for survival.

关 键 词：肝门部胆管癌 切除 生存时间 多因素分析 预后 

分 类 号：R735.8[医药卫生—肿瘤]