脑梗死患者内脂素和基质金属蛋白酶-9与颈动脉粥样硬化斑块易损性的关系  

The Relationship of Serum Visfatin and MMP-9 with the Vulnerability of Carotid Atherosclerotic Plaque in Ischemic Cerebrovascular Disease

作　　者：段新辉[1] 王蓉[1] 徐超[2] 李晓军[1] 申静[1] 王宏[1] 

机构地区：[1]石河子大学医学院第一附属医院神经内科,新疆石河子832002 [2]石河子大学医学院第一附属医院彩超室,新疆石河子832002

出　　处：《现代生物医学进展》2014年第3期500-502,共3页Progress in Modern Biomedicine

摘　　要：目的:探讨血清内脂素(Visfatin)及基质金属蛋白酶-9(MMP-9)水平与脑梗死患者颈动脉粥样硬化斑块稳定性的关系和血清visfatin和MMP-9的相关性。方法:选择脑梗死患者70例,根据颈动脉粥样硬化斑块性质分为易损性斑块组(n=43)和非易损性斑块组(n=27),选取健康体检者30例作为对照组。测定血清Visfatin和MMP-9水平,并对二者间关系进行相关分析。结果:脑梗死伴颈动脉硬化组血清Visfatin、MMP-9水平高于正常对照组(P<0.01);易损性斑块组血清Visfatin和MMP-9水平高于非易损性斑块组,差异有统计学意义(P<0.017)。外周血中的Visfatin水平与MMP-9呈正相关关系(r=0.643,P=0.000)。结论:在脑梗死患者中,血清Visfatin和MMP-9参与了颈动脉粥样硬化的病理生理过程,Visfatin和MMP-9升高可能与颈动脉粥样硬化斑块不稳定性的形成相关,Visfatin可通过调控MMP-9的分泌和活性从而改变斑块的易损性。Objective： To explore the relationship of Visfatin and MMP-9 with the vulnerability of carotid atherosclerotic plaque and the correlation of serum Visfatin and MMP-9. Methods： According to the carotid atherosclerosis plaque vulnerability, 70 patients with cerebral infarction were divided into vulnerable plaque group （n=43） and unvulnerable plaque group （n=27）. Thirty healthy subjects were selected as controls （control group）. The levels of serum Visfatin and MMP-9 were examined, and analyse the correlation between them. Results： The level of Visfatin and MMP-9 in the Cerebral infarction associated with carotid atherosclerosis group was significantly higher than that in control group （P〈0.01）. The level of Visfatin and MMP-9 in the vulnerable plaque group was higher than that in the unvulnerable plaque group and control group （P 〈0.017）. A positive correlation was observed between the expression of Visfatin and MMP-9 in vitro （r=0.643, P=0.000）. Conclusion： The serum Visfatin and MMP-9 participated in the pathophysiological process of carotid atherosclerosis in cerebral infarction patients, it may be correlation high levels of Visfatin and MMP-9 with the formation of caotid atheroscleotic plaque instability, Visfatin may be regulate MMP-9 secretion and activity, which changes plaques vulnerability.

关 键 词：内脂素 基质金属蛋白酶-9 脑梗死 颈动脉粥样硬化 易损性 

分 类 号：R743.3[医药卫生—神经病学与精神病学]