Pokemon及其在肿瘤中的研究进展  

Progress on the Research of Pokemon and its Function in Tumors

作　　者：刘鑫远[1] 禹亮[1] 张健[1] 王磊[1] 

机构地区：[1]哈尔滨医科大学附属第一医院胸外科,黑龙江哈尔滨150001

出　　处：《现代生物医学进展》2014年第3期575-577,582,共4页Progress in Modern Biomedicine

基　　金：黑龙江省卫生厅科研课题(2010-039);哈尔滨医科大学第一医院科研基金(2009L05)

摘　　要：Pokemon基因即POK红系髓性致癌因子,也被称为FBI-1,LRF,OCZF,TIP,它是POK转录抑制物家族成员之一,其编码的产物具有BTB/POZ域和锌指结构,它是第一个被发现的可变阅读框基因ARF(Alternative reading frame,ARF)的特异性转录抑制物,Pokemon通过特异抑制ARF转录来调控细胞周期、诱导肿瘤发生、促进肿瘤的发生发展,在一些人类肿瘤如食管鳞癌、肺癌、结肠癌、人贲门癌、膀胱癌,前列腺癌和乳腺癌等肿瘤组织中具有较高的表达水平。Pokemon的特殊性在于还能与其它癌基因如Bcl-2,MDM2等结合之后发挥作用来促进其他癌基因的活性。因此可以认为Pokemon是肿瘤的总开关,对Pokemon基因的进一步研究有助于为肿瘤的诊断和治疗提供新的途径和方法。： The Pokemon gene that is POK erythroid myeloid carcinogen, also called the FB1-1, LRF, OCZF, TIP, it is one of the POK transcription inhibitor family members, encoding product has BTB / POZ domain and zinc finger, it is the first to be found in the variable reading frame gene ARF（ Alternative reading frame ,ARF ） specific transcription inhibitor. Pokemon which inhibitates the ARF transcriptional specifically is to regulate the cell cycle and induce tumor to promote tumor development. It has a high-leveled expression in some human tumors such as esophageal squamous cell carcinoma, lung cancer, colon cancer, people cardia cancer and bladder cancer, prostate cancer, breast cancer and other tumor tissues. The specificity of Pokemon is to promote the role of other oncogenes. Therefore, Pokemon is considered to be the master switch of tumors. The further research of the Pokemon gene is to help to provide new ways and means for the diagnosis and treatment oftmnors.

关 键 词：POKEMON ARF 癌症 

分 类 号：R730.231[医药卫生—肿瘤]