2型糖尿病脑梗死患者血浆血栓调节蛋白水平及其临床意义  

Plasma Thrombomodulin Level and its Clinical Significance in Cerebral Infarction in Diabetes

作　　者：王蓉[1] 王宏[1] 赵鸿雁[1] 段新辉[1] 申静[1] 

机构地区：[1]石河子大学医学院第一附属医院神经内科,新疆石河子832002

出　　处：《现代生物医学进展》2014年第4期731-734,共4页Progress in Modern Biomedicine

摘　　要：目的:探讨血浆可溶性血栓调节蛋白(soluble thrombomodulin,sTM)与2型糖尿病脑梗死(type2 diabetes mellitus cerebral infarction,DMCI)的关系及其临床意义。方法:选择2011年12月至2012年8月我科收治的急性脑梗死(acute cerebral infarction,ACI)患者60例,其中DMCI患者30例,非2型糖尿病合并脑梗死(non-diabetes mellitus cerebral infarction,NDMCI)患者30例,以及同期健康体检者30例。采用酶联免疫吸附法(ELISA)检测其血浆sTM水平,并按美国国立卫生研究所脑卒中评分(NIHSS)进行临床神经功能缺损评估。结果:(1)与正常对照组相比,DMCI组及NDMCI组患者血浆sTM水平均明显升高,差异有统计学意义(P<0.01);(2)DMCI组患者血浆sTM水平和NIHSS评分均较NDMCI组显著升高,差异有统计学意义(P<0.01);(3)DMCI组和NDMCI组患者血浆sTM水平与NIHSS评分呈显著正相关,(r=0.785,P<0.001)。结论:2型糖尿病脑梗死患者血浆sTM水平较正常人群显著升高,且与其神经功能缺损的严重程度呈显著正相关,检测血浆sTM水平可有助于评估2型糖尿病合并脑梗死的分期、严重程度及其转归。Objective： To explor changes and clinical significance of plasma soluble thrombomodulin （sTM） level in diabetes mellitus cerebral infarction （DMCI）. Methods： from December 2011 to August 2012, 60 Acute Cerebral Infarction patients treated in our hospital were selected and their data were collected, 30 cases with typy2 diabetes mellitus （DM） and 30 Non- typy2 diabetes mellitus cerebral infarction （NDM） cases, and 30 healthy subjects over the same period were as control, the plasma sTM level were detected by enzyme linked immunosorbent assay （ELISA）, and the seventies of neurological impairment were assessed by the National Institute of Health Stroke Scale score （NIHSS）. Results： （1）As compared to healthy subjects, the plasma level of sTM both in DMCI group and NDMCI group were higher （P〈0.01）. （2）The level of DMCI plasma sTM and NIHSS scores compared with NDMCI group increased significantly, the difference was statistically significant （P〈0.01）. （3）The plasma level ofsTM and NIHSS score is significantly positive correlation in DMCI group and NDMCI group （r=0.786, P〈0.001）. Conclusion： The plasma level of sTM in DMCI group is inceased significantly than normal group, and it is significant positive correlation with severity of neurological impairment. It suggested that the plasma level ofsTM can be helpful in assessing the stage,severity and outcome of type 2 diabetes mellitus cerebral infarction.

关 键 词：可溶性血栓调节蛋白 脑梗死 2型糖尿病 神经功能缺损 

分 类 号：R743.3[医药卫生—神经病学与精神病学]