新生儿胰岛母细胞增生症伴高胰岛素血症低血糖2例并文献复习  

Neonatal nesidioblastosis with hyperinsulinemia hypoglycaemia: report of two cases and review of literatures

作　　者：马靖[1] 殷敏智[1] 沈萍[1] 陈洁枫[1] 金晓婷[1] 张忠德[1] 

机构地区：[1]上海交通大学附属上海儿童医学中心病理科,上海200127

出　　处：《临床与实验病理学杂志》2014年第2期189-192,共4页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的探讨新生儿胰岛母细胞增生症伴高胰岛素血症低血糖的临床病理学特征、诊断及鉴别诊断。方法对2例新生儿胰岛母细胞增生症行HE、免疫组化染色,光镜下观察,并复习相关文献。结果 HE染色见病变胰腺组织中,弥漫或局灶胰岛数量增多,部分体积增大,形状及大小不规则。免疫组化染色示大量神经内分泌标记阳性的细胞分布于胰岛或单个散在分布于胰腺组织。结论新生儿胰岛母细胞增生症伴有高胰岛素低血糖,临床及影像学诊断困难,组织病理学检查可确诊,能够给予及时正确的治疗,挽救新生儿生命。Purpose To explore clinicopathological features of neonatal nesidioblastosis with hyperinsulinemia hypoglycaemia as well as its differential diagnosis. Methods The clinical features, histopathology and immunohistochemistry of two cases of nesidioblastosis were studied with review of related literature. Result Sections of HE stain showed focal or diffused increase in numbers of islets with variable enlarged size and irregular shape. Immunohistochemistry showed the neuroendocrine positive cells scattered in the islets in the pancreas. Conclusion Neonatal nesidioblastosis with hyperinsulinemia hypoglycaemia is always easily confused with other diseases and the diagnosis and differential diagnosis rely mainly on histopathological and immunohistochemical findings which will give help to the proper treatment and even save the baby＇ s lives.

关 键 词：胰岛母细胞增生症 高胰岛素血症 低血糖 儿科 病理组织学 

分 类 号：R736.7[医药卫生—肿瘤]