黑质致密部FA值和T_2*值对诊断早期帕金森病的比较研究  

A comparative study of FA and T2 *values of the substantia nigra pars compacta for diagnosis of early Parkinson′s disease

作　　者：陈燕生[1] 方元[1] 史文宗[2] 刘德丰[1] 吴爽[1] 杜丹[1] 刘兰祥[1] 

机构地区：[1]秦皇岛市第一医院核磁科,河北066000 [2]秦皇岛市第一医院信息科统计室,河北066000

出　　处：《放射学实践》2014年第2期155-158,共4页Radiologic Practice

摘　　要：目的:对早期帕金森病(PD)黑质致密部FA值及T2*值进行比较研究,探讨早期PD更准确的诊断方法。方法:对20例早期PD患者及28例性别、年龄相匹配的正常志愿者行磁共振扩散张量成像(DTI)、多回波采集T2*WI三维梯度回波(ESWAN)及T2WI序列扫描;以T2WI为参考图像,手工勾勒黑质致密部各感兴趣区(ROI),分别测量DTI及ESWAN序列各ROI的FA值及T2*值并进行统计学分析。结果:早期PD黑质致密部头、体及尾部FA值较正常对照组均有统计学差异(P均<0.05);头、体及尾部T2*值较正常对照组亦均有统计学差异(P均<0.05);早期PD黑质致密部内、外侧FA值较对照组组间均有统计学差异(P均<0.05),而T2*值在各组间均无统计学差异(P均>0.05);早期PD黑质致密部FA值及T2*值组内内、外侧之间均无统计学差异(P均>0.05)。结论:对早期PD的诊断FA值较T2*值更趋于准确。Objective：To compare the FA and T2 ＊ values of the substantia nigra pars compacta in early Parkinson＇s disease, thus to explore more accurate diagnostic method of early Parkinsonrs disease. Methods： 20 patients with early Par- kinson＇s disease and 28 cases of gender and age-matched normal volunteers were scanned by DTI, ESWAN and T2 WI;Using T2 WI image for reference,hand-sketched regions of interest in the substantia nigra were determined and FA and T2 ＊ values of each region of interest were measured. Results：There was statistical significant difference between FA values of the ros- tral,middle and caudal region of substantia nigra pars compacta in early PD and FA values of those of normal control group after refining （P^0.05）. There was statistical significant difference between T2 ＊ values of the rostral,middle and caudal region of substantia nigra pars compacta between T2 ＊ values of those of normal control group after refining （P^0.05）. There was statistical significant difference between FA values of medial and lateral region of substantia nigra pars compacta in early PD and FA values of those in control group （P〈0.05） ,while there was no statistical significant difference of T2 ＊ values between above mentioned groups （P〉O. 05）. There were no statistical significant difference of FA values and T2 ＊ values between medial and lateral region of substantia nigra pars compacta in early PD （P〉0.05）. Conclusion： FA value is more accurate than T2 ＊ value for the diagnosis of early Parkinson% disease.

关 键 词：磁共振成像 帕金森病 

分 类 号：R742.5[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]