不同疾病类型的帕金森病患者非运动症状发生率的比较  

Comparison of the prevalence of nonmotor symptoms between subtypes of Parkinson disease

作　　者：马敬红[1] 邹海强[2] 安静[3] 陈彪[1] 

机构地区：[1]首都医科大学宣武医院神经内科,北京100053 [2]广州军区广州总医院神经内科,广东广州510010 [3]首都医科大学宣武医院老年病研究所,北京100053

出　　处：《中风与神经疾病杂志》2014年第2期136-138,共3页Journal of Apoplexy and Nervous Diseases

基　　金：国家高技术研究发展计划(863)资助项目(2006AA02A408);国家重点基础研究发展计划(973)资助项目(2011CB504101);科技部973计划重大科学问题导向项目(2011CBA00408)

摘　　要：目的了解帕金森病(Parkinson’s disease,PD)不同疾病类型在非运动症状发生率上的差异。方法连续选取门诊确诊为原发性PD的301例患者,详细记录其起病年龄等临床资料,评定非运动症状筛查量表、统一帕金森病评分量表等。所得资料进行统计学分析。结果 301例患者中109例为震颤型,143例为姿势步态异常(postural instability and gait difficulty,PIGD)型,49例为中间型。震颤型和PIGD型在非运动症状总数、起病年龄、UPDRS第3部分总分、CES-D抑郁自评量表总分、汉密尔顿抑郁量表总分以及病程上均存在显著性差异(P<0.05)。PIGD型在白天流涎、尿急、疼痛、情绪低落、跌倒和下肢浮肿等16个非运动症状的发生率上均高于震颤型(P<0.05)。结论震颤型和PIGD型在多个临床特征上存在差异。PIGD型更易出现白天流涎、尿急、疼痛、情绪低落、跌倒和下肢浮肿等非运动症状。Objective To compare the prevalence of nonmotor symptoms between subtypes of Parkinson disease. Methods The detailed clinical information of 301 patients with idiopathic PD was recorded and followed up. The data were calculated with SPSS statistic software. Results Among the 301 patients, 109 were tremor-dominant PD, 143 were PIGD- dominant type and 49 were intermediate type. There were significant differences in the sum of nonmotor symptoms, onset age, the total scores of UPDRS part Ill, CES-D score, Hamilton depression scale score and disease duration between tremor- dominant and PIGD-dominant PD（P 〈 0.05 ）. PIGD type has higher prevalence of daytime dribbling, urgency, pains, sad, falling and sweating etc. than the tremor-dominant type （ P 〈 0.05 ）. Conclusion There are significant differences in sever- al clinical characteristics between the tremor-dominant and PIGD-dominant PD. The PIGD type may be more likely to have the nonmotor symptoms like daytime dribbling, urgency, pains, sad ,falling and sweating etc.

关 键 词：帕金森病 非运动症状 疾病类型 

分 类 号：R742.5[医药卫生—神经病学与精神病学]