术后临床分期及CD_(57)^+细胞水平对喉癌患者生存预后的评价  

Prognostic significance of CD_(57)^+ cell level and pTNM staying system in patients with laryngeal cancer

作　　者：郑美桦[1] 栾信庸[2] 

机构地区：[1]山东省济宁市第一人民医院耳鼻咽喉科 [2]山东医科大学附属第一医院耳鼻咽喉科,济南250012

出　　处：《临床耳鼻咽喉科杂志》2001年第2期73-76,共4页Journal of Clinical Otorhinolaryngology

摘　　要：目的 :探讨喉癌患者术后临床分期 (p TNM)及其外周血 CD5 7+ 细胞水平对其生存率的影响。方法 :对 34例喉癌患者 [T1～ 2 13,T3～ 42 1例 ;声门上癌 8例 ,声门癌 2 3例 ,声门下癌 3例 ;淋巴结转移 (p N+ ) 10例 ,无淋巴结转移 (p N0 ) 2 4例 ;高分化 (G1 ) 11例 ,中分化 (G2 ) 13例 ,低分化 (G3) 10例 ]及 16例健康人 (对照组 )以 SAP法测定单克隆抗体 CD5 7+ 标记的阳性细胞百分率。术后随访 6 0个月 ,观察 p TNM分期、病理分级、肿瘤生长部位和CD5 7+ 细胞水平与患者生存率的关系。结果 :随访第 12个月末 ,T1～ 2 与 T3～ 4,p N0 与 p N+ ,G1 与 G2 ,3,CD5 7+ ≥ 15 %与 CD5 7+ <15 % ,声门上癌与声门癌及声门下癌之间生存率差异显著 (P <0 .0 5 )。第 2 4个月和第 31个月 ,T1～ 2与 T3～ 4的生存率差异无显著性意义 (P >0 .0 5 ) ,其余指标则差异显著 (P <0 .0 5 )。第 48个月末 ,T1～ 2 与 T3～ 4,G1与 G2 ,3的生存率差异亦无显著性意义 (P >0 .0 5 ) ;只有 p N0 与 p N+ 、CD5 7+ ≥ 15 %与 CD5 7+ <15 % ,声门上癌与声带癌和声门下癌比较 ,其生存率差异显著 (P <0 .0 5 )。 CD5 7+ 细胞水平在 p N0 组明显低于 p N+ 组及对照组 (P <0 .0 5 )。分析 p N+ 和 CD5 7+ 细胞≥ 15 %及 p N0 和 CD5 7+ ?Objective:To analyze the prognostic value of the pTNM clinical staying system,as well as the CD 57 + cells level in peripheral blood samples of the patients with laryngeal carcinoma.Method:The CD 57 + cells level of peripheral blood was determined with SAP method in 34 patients with laryngeal carinoma and 16 normal subjects.The pTNM clinical stage was T 1 2 in 13,T 3 4 in 21;pN + in 10, pN 0 in 24;supraglottis in 8,glottis in 23;hypoglottis in 3;pathologic differentiation G 1 in 11,G 2,3 in 23.Result:The CD 57 + cells level significantly increased (pN + vs.pN O).In the 12nd month actual survival were significantly different (T 1,2 vs.T 3,4 ,pN 0 vs.pN +,G 1 vs G 2、3 ,supraglottis vs.glottis and hypoglottis,CD 57 +≥15% vs.CD 57 +<15%).In the 24th month and 36th month actual survival were significantly different (pN 0 vs.pN +,G 1 vs G 2、3 ,supraglotisvs.glottis and hypoglottis,CD 57 +≥15% vs.CD 57 +<15%).In the 48th month actual survival were significantly different only (pN 0 vs.pN +,supraglottis vs.glottis and hypo glottis,CD 57 +≥15% vs.CD 57 +<15%).Conclusion:These results suggested that the assessment of pTNM system and the CD 57 + cells level have significance for prognosis of patients with laryngeal carcinoma.

关 键 词：喉肿瘤 肿瘤分期 预后 CD57+抗原 喉癌 生存 

分 类 号：R739.65[医药卫生—肿瘤]