氟西汀对急性前循环脑梗死运动恢复的临床研究  

The clinical research of fluoxetine on motor functional recovery after the acute cerebral infarction in anterior circulation

作　　者：刘海涛[1] 冯来会[1] 白宏英[2] 

机构地区：[1]郑州人民医院神经内科,郑州450000 [2]郑州大学第二附属医院神经内科,郑州450014

出　　处：《中国实用神经疾病杂志》2014年第1期28-30,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的 观察氟西汀对急性前循环脑梗死3个月后运动功能的恢复作用.方法 选择入院的急性前循环缺血性脑梗死偏瘫患者60例,平均年龄46～70岁.采用单盲法随机分为治疗组和对照组各30例,治疗组在给予常规治疗的同时,在发病3～10 d内晨服氟西汀20 mg,1次/d,持续3个月.对照组给予常规治疗.3个月后使用FuglMeyer 量表（FMA）评价患者上肢运动功能,应用功能独立性评定量表（FIM）评价进食、梳洗、穿脱上衣等功能.结果 3个月后治疗组FuglMeyer motor scale （FMMS）及FIM评分明显高于对照组（P〈0.05）,差异有统计学意义.结论 及早的给予氟西汀,有助于运动功能的改善,氟西汀可能参与促进神经功能的修复.Objective To observe the effects of fluoxetine on motor functional recovery at 3 months after the acute infarc- tion in anterior circulation. Methods Acute cerebral infarction in anterior circulation patients with hemiplegia （n= 60） were de- lected, and the average age was 46--70 years old. 60 patients were randomly divided into the treatment group and the control group by single-blind method, each treatment group was received conventional therapy, but at the same time, the treatment group received oral fluoxetine 20mg once a day （in the morning） when at the onset of within 3--10 days after administration, for three months. After 3 months, upper limb motor function was evaluated by Fugl-Meyer Scale in each group, and the evalu- ation of eating, grooming, wearing off his coat and other functions were measured by Functional Independence Measure Scale （FIM）. Results Fugl-Meyer motor scale （FMMS） and the FIM score in the treatment group were significantly higher than the control group （P〈0.05）. Conclusion Early Fluoxetine treatment could contribute to the improvement of motor function the a- cute infarction in anterior circulation , and it may be involved in the restoration of neurological function.

关 键 词：急性前循环脑梗死 氟西汀 FMMS FIM评分 

分 类 号：R743.33[医药卫生—神经病学与精神病学]