α-硫辛酸联合疏血通治疗急性脑梗死的疗效观察  

Clinical efficacy of alpha lipoic acid combined with Shuxuetong on acute cerebral infarction

作　　者：陈绍辉[1] 李东航[1] 赖汉齐[1] 

机构地区：[1]南方医科大学附属普宁华侨医院神经内科,普宁515300

出　　处：《中国实用神经疾病杂志》2014年第4期12-14,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的观察α-硫辛酸联合疏血通治疗急性脑梗死患者的临床疗效。方法收集本院住院治疗的80例急性脑梗死患者,随机分为实验组和对照组各40例。对照组以常规治疗为主,实验组在常规治疗的基础上加用α-硫辛酸和疏血通静脉注射治疗。分别于用药前及用药后14d对2组患者神经功能缺损(NIHSS)评分、改良Rankin量表(MRS)评分、Barthel指数、血液凝血指标、总有效率及不良反应进行比较。结果治疗后2组NIHSS评分及MRS评分下降,Barthel指数上升,且血液凝血指标有所改善,实验组优于对照组(P<0.05);治疗后实验组临床疗效高于对照组(P<0.05);2组均未发现不良反应。结论α-硫辛酸联合疏血通治疗急性脑梗死有助于提高临床疗效,可能与α-硫辛酸抗氧化保护脑细胞和疏血通抗凝改善血液凝血指标有关。Objective To observe the efficacy of alpha lipoic acid combined with Shuxuetong on acute cerebral infarc- tion. Methods 80 cases of acute cerebral infarction patients were randomly divided into experimental group（n=40） and control group（n= 40）. Control group were given conventional treatment,and experimental group were given alpha lipoic acid combined with Shuxuetong therapy based on the conventional treatment of the control group. The neural function defect score （NIHSS）, modified Rankin scale （MRS） score, Barthel index, clotting index, the total effective rate and adverse reaction were compared in two groups. Results NIHSS score and MRS score all decreased, Barthel index rose, and clotting index had improved after treatment in two groups, and those of the experimental group was all better than those of the control group （P〈0.05）. No ad- verse reactions were found in two groups. Conclusion Alpha lipoic acid combined with Shuxuetong can help improve the effica- cy of acute cerebral infarction. The mechanism may be that alpha lipoic acid can protect brain cells by oxidation and Shuxuetong can improve clotting index through anticoagulation.

关 键 词：Α-硫辛酸 疏血通 急性脑梗死 

分 类 号：R743.33[医药卫生—神经病学与精神病学]