微血管密度和Ki-67指数与星形胶质瘤临床病理关系的研究  

The Relationship Between MVD、Ki-67LI and Clinical Pathology in Astrocytoma

作　　者：李志强[1] 袁先厚[1] 张望来[1] 陈卫国[1] 

机构地区：[1]湖北医科大学附二医院脑外科,430071

出　　处：《实用癌症杂志》2001年第1期16-17,共2页The Practical Journal of Cancer

摘　　要：目的　寻求判断星形胶质瘤恶性程度和预后的量化指标。方法　采用免疫组化染色技术对 48例星形胶质瘤组织微血管密度 (MVD )和Ki 6 7指数 (Ki 6 7LI)进行测定。结果　低度恶性肿瘤中MVD和Ki 6 7LI分别为 8.89± 5 .80和 6 .6 9± 4.81,在高度恶性肿瘤中分别为 17.49± 13 .13和 2 3 .6 2± 6 .78,具有显著性差异 ;术后生存 2年以上者 ,其 2个指标值均低于术后生存不足 2年者。但MVD和Ki 6 7LI在不同性别、年龄间的比较 ,无显著性差异。结论　MVD和Ki 6 7LI均可作为判断星形胶质瘤恶性程度和预后的指标 ;同时检测两者可互为补充。Objective To find the quantitative indexes for the malignant grade and prognosis of astrocytoma.Methods Immunoshistochemistry staining was used to detect microvascular density(MVD) and Ki 67 labelling index(Ki 67LI) in 48 cases of astrocytoma tissue.Results In low grade astrocytoma,MVD and Ki 67LI were 8.89±5.80 and 6.69±4.81 respectively;while in high grade astrocytoma,they were 17.49±13.13 and 23.62±6.78 respectively.The difference was significant( P <0.05).There was also significant difference of two indexes in different prognosis.Conclusion The two indexes,MVD and Ki 67LI,are useful in judging the malignant grade and prognosis of astrocytoma.They are also complementary each other.

关 键 词：微血管密度 KI-67指数 星形细胞瘤 病理 

分 类 号：R730.264[医药卫生—肿瘤]