婴儿色素性神经外胚瘤的临床病理研究  

Clinicopathological Study of Melanotic Neuroectodermal Tumor in Infancy

作　　者：赵海滨[1,2] 石群立[1] 金行藻[1] 孙桂勤[1] 陆珍风[1] 严小娟[1] 杨震[1] 

机构地区：[1]南京军区南京总医院病理科,解放军第101医院病理科210002 [2]解放军第101医院病理科

出　　处：《实用癌症杂志》2001年第1期54-56,共3页The Practical Journal of Cancer

摘　　要：目的　探讨婴儿色素性神经外胚瘤的临床病理特点。方法　对 2例婴儿色素性神经外胚瘤进行临床资料分析和组织病理学、免疫组织化学及电镜观察。结果　该肿瘤多发生于 1岁以内的婴幼儿。主要发生在上、下颌骨 ,呈浸润性生长、溶骨性破坏。组织学特征为 :肿瘤由含色素的上皮样细胞和小的神经母细胞样细胞构成。免疫组化结果为 :上皮样瘤细胞表达CK、EMA、HMB45、S 10 0蛋白及Vim ,小的瘤细胞则表达NSE ,Syn及Vim。超微结构观察 :大的瘤细胞质内含黑色素小体 ,小的瘤细胞质内见神经内分泌颗粒。结论　婴儿色素性神经外胚瘤起源于原始的神经外胚层细胞 ,为低度恶性肿瘤。Objective To investigate the clinicopathological features of infancy melanotic neuroectodermal tumor.Methods Clinical histopathological,immunohistochemcal,ultrastructural observation were done in 2 cases of infancy melanotic neuroectodermal tumor.Results The tumor occurred in infants under 1 year of age.Tumor sat in the maxilla mandible.Aggressive behavior and osteolytic destruction were observed.Histopathologically the tumor was composed of small neuroblastic cell and larger melanin containing epithelial cells.Immunohistochemically epithelial cells expreessed CK,EMA,HMB45,S 100 protein and small neuroblastic cells expressed NSE,Syn and Vim.Ultrastructure obserration showed that larger cells had melanosomes and small cells had neurosecretory granules.Conclusion The study indicates that the tumor origins from neural crest and is low malignancy.

关 键 词：婴儿 色素性神经外胚瘤 免疫组织化 超微结构 

分 类 号：R730.264[医药卫生—肿瘤]