散发性结直肠癌发病分子机制研究进展  

Research Progress in Molecular Pathogenesis of Colorectal Cancer

作　　者：毛盈颖 李迎君[1] 陈坤[1] 

机构地区：[1]浙江大学公共卫生学院,浙江杭州310058

出　　处：《中国肿瘤》2014年第2期97-102,共6页China Cancer

基　　金：国家自然科学基金(81072356;81373087)

摘　　要：结直肠癌是最常见的消化系统恶性肿瘤之一,其病因和发病机制十分复杂。自1974年Morson提出结直肠腺瘤癌变序贯学说以来,随着现代分子生物学技术的飞速发展,研究者对结直肠癌发病的分子机制进行了深入研究。目前认为,结直肠癌的发生是一个多因素、多步骤、内外因交互作用的结果,且具有鲜明的分子特征,主要包括癌基因的激活、抑癌基因的失活及基因组不稳定现象等。全文主要围绕结直肠癌发病分子机制的最新研究进展作一综述。Colorectal cancer（CRC） is one of the most common digestive system malignancies,and the etiological factors and pathogenetic mechanisms underlying CRC development appear to be com- plex and heterogeneous. Since Morson first proposed ＂the adenoma-carcinoma sequence＂ in 1974, the pathogenesis of CRC has been extensively studied with the rapid advancement of the molecular biological techniques. The development of CRC is recognized as a multi-factorial,multi-stage pro- cess with intense crosstalk of both genetic and environmental risk factors, and has distinct molecu- lar characteristics, such as activation of oncogenes,loss-of-function of tumor suppressor genes, and genomic instability. In this review,the most up-to-date progresses in the study of molecular patho- genesis of CRC are discussed.

关 键 词：结直肠癌 发病机制 染色体不稳定 微卫星不稳定 CpG甲基化表型 

分 类 号：R735.34[医药卫生—肿瘤]