14-3-3σ蛋白在胃癌中的表达及其与临床病理特征的关系  

The relationship of expression of 14-3-3σ protein in gastric canc er and its clinical pathological characteristics

作　　者：曾超[1] 李应广 古超云 林翠霞[1] 

机构地区：[1]广东医学院基础医学院病理学教研室,广东东莞523808

出　　处：《现代医药卫生》2014年第5期653-654,657,共3页Journal of Modern Medicine & Health

基　　金：2011年广东医学院大学生创新实验项目科研项目(2011ZZDB004);2012年广东省大学生创新创业训练计划项目(1057112029)

摘　　要：目的利用胃癌组织芯片探讨14-3-3σ蛋白在胃癌中的表达及其与临床病理特征之间的关系。方法应用免疫组织化学链霉素抗生素蛋白-过氧化物酶连结法检测75例胃癌患者癌组织及癌旁正常组织中14-3-3σ蛋白的表达情况,并结合临床病理资料进行统计学分析。结果 14-3-3σ蛋白在胃癌中表达的阳性率为88.0%,在癌旁正常组织中为34.7%,差异有统计学意义(P<0.05)。胃癌组织中14-3-3σ蛋白的表达与肿瘤大小有关(P<0.05)。结论 14-3-3σ蛋白在胃癌组织中表达上调,其表达与胃癌增殖密切相关。Objective To explore the relationship of expression of 14-3-3σ in gastric cancer and its clinical pathological characteristics by gastric cancer tissue chip. Methods The 14-3-3σ protein levels in 75 cases of gastric cancer and normal tis sues near the cancer were detected by immunohistochemical streptavidin-peroxidase （SP） method, and combining with clinicopathologic data,the statistical analysis was conducted. Results The positive expression rate of 14-3-3σ protein was 88.0% in gastric cancer tissue and 34.7% in normal tissue near cancer with statistically significant difference （P〈0.005）. The expression of 14-3-3σ protein in gastric cancer tissue was associated with tumor size （P〈0.005）. Conclusion 14-3-3σ protein is up-regulated in gastric cancer, and its expression is closely related with proliferation of gastric cancer cells.

关 键 词：蛋白质类 胃肿瘤 病理学 免疫组织化学 组织芯片 

分 类 号：R735.2[医药卫生—肿瘤]