艾司西酞普兰对躯体形式障碍患者认知功能的影响  

Effect of ascitalopramb on cognitive function in patient with somatoform disorders

作　　者：谢国军[1] 刘锐[1] 赵长江[1] 邓文[1] 黎雪松[1] 

机构地区：[1]佛山市第三人民医院,528041

出　　处：《临床精神医学杂志》2014年第1期39-41,共3页Journal of Clinical Psychiatry

基　　金：广东省医学科研基金项目(A2010603)

摘　　要：目的:探讨艾司西酞普兰对躯体形式障碍患者认知功能的影响。方法:60例躯体形式障碍患者(病例组)接受艾司西酞普兰治疗6周;治疗前后分别行瑞文标准推理测验、成人韦氏智力测验中数字广度及数字符号测验、以及事件相关电位P300检测;结果与60名健康者(对照组)比较。结果:病例组治疗前瑞文、数字广度及符号测验评分(84.78±13.85、11.22±1.61、10.95±2.45)明显低于对照组(96.52±18.18,12.63±2.66,12.83±1.49;P均<0.01),P300 N1潜伏期[(101.96±9.38)ms]明显长于对照组[(90.17±7.99)ms](P<0.001);治疗后瑞文及数字广度评分(91.25±14.87,11.98±1.89)明显增加,P300 P2及N2潜伏期[(194.64±65.31)ms,(240.60±41.41)ms]明显延长(P<0.05或P<0.01)。结论:艾司西酞普兰可改善躯体形式障碍患者的认知功能。Objective： To investigate the effect of escitalopram on cognitive function in patient with somatoform disorders.Method：Sixty somatoform disorders （case group） were treated with ascitalopramb for 6 weeks.Before and after treatment, they were assessed by Raven standard progressive matrices test,digit span and digit symbol tests in adult Wechsler intelligence test and detected by event-related potentials P300, respectively.The results were compared with 60 normal controls （control group）.Results：The scores of Raven,digit span and digit symbol （84.78±13.85,11.22±1.61,10.95±2.45）in case group were significant lower,the N1 incubation period of P300[（101.96±9.38）ms]was significant longer than those in control group[（96.52±18.18）,（12.63±2.66）,（12.83±1.49）,（ 90.17±7.99） ms;allP＜0.01）]. After treatment, the scores of Raven and digit span （91.25±14.87,11.98±1.89） were significantly increased, the latent periods of P2 and N2[ （194.64±65.31）ms,（240.60±41.41）ms]were prolonged than before treatment（P〈0.05 or P〈0.01）.Conclusion：Escitalopram can improved cognitive function in somatoform disorders.

关 键 词：艾司西酞普兰 躯体形式障碍 认知功能 

分 类 号：R749.7[医药卫生—神经病学与精神病学]