氯霉素治疗小儿难治性化脓性脑膜炎的疗效和安全性分析  

Analysis on efficacy and security of chloramphenicol in the treatment of intractable bacterial meningitis

作　　者：张晓莉[1] 贾天明[1] 牛国辉[2] 徐庆荣[1] 张艳丽[1] 

机构地区：[1]郑州大学第三附属医院儿内科,河南郑州450052 [2]郑州大学第三附属医院康复医学中心

出　　处：《中国妇幼保健》2014年第8期1281-1283,共3页Maternal and Child Health Care of China

基　　金：河南省教育厅科技项目〔(2013)68号〕

摘　　要：目的:研究氯霉素对难治性化脓性脑膜炎的疗效和安全性。方法:回顾性分析近8年来医院应用氯霉素治疗的32例难治性化脓性脑膜炎患儿,评价其疗效和不良反应。结果:32例应用抗感染药物控制不佳的难治性化脓性脑膜炎患者,加用氯霉素后31例症状好转,脑脊液正常,临床治愈;1例治疗第3周时脑脊液培养提示合并真菌性脑膜炎,家属放弃治疗。胃肠道不良反应15例,均表现为呕吐、良欲差,停药后很快消失。所有患儿未出现明显肝肾功能损伤。结论:氯霉素治疗难治性化脓性脑膜炎疗效确切,不良反应少。Objective： To study the efficacy and security of chloramphenicol in the treatment of intractable bacterial meningitis. Methods： The treatment of intractable bacterial meningitis cases （32 cases） treated by chloramphenicol were analyzed retro- spectively in recent 8 years, and its efficacy and adverse reactions were evaluated. Results： 32 cases treated by anti -infective drugs resul- ting from poor curative effect, among which 31 cases were improved with receive symptoms, the normal cerebrospinal fluid , clinical cure and less adverse reaction after adding chloramphenicol. 1 case with fungal meningitis given up treatment. 15 cases of gastrointestinal adverse reaction were characterized by vomiting, poor appetite, disappeared soon after stopping drug. All patients showed no obvious damage to liver and kidney function. Conclusion： The efficacy of chloramphenicol in intractable suppurative meningitis is certain, furthermore , the ad- verse reaction is less.

关 键 词：化脓性脑膜炎 氯霉素 不良反应 治疗效果 

分 类 号：R725[医药卫生—儿科]