钙信号在恶性肿瘤侵袭迁移中的作用  

Role of calcium signaling in neoplasms invasion and migration

作　　者：朱蒙[1] 杨学军[1] 

机构地区：[1]天津医科大学总医院神经外科,300052

出　　处：《国际肿瘤学杂志》2014年第3期161-164,共4页Journal of International Oncology

基　　金：国家自然科学基金（81272782）;高等学校博士学科点专项科研基金（20131202110006）

摘　　要：细胞内钙参与体内的多种生理病理过程。钙信号异常与恶性肿瘤的侵袭迁移行为密切相关。钙通过影响钙蛋白酶（calpain）、富含脯氨酸的酪氨酸激酶2（PYK2）、S100蛋白家族等下游相关蛋白的活性，调控黏着斑周转、细胞骨架重构以及肿瘤细胞运动的其他环节。包括钙池操纵的钙通道及瞬时受体电位通道在内的数种钙通道参与了肿瘤的侵袭迁移过程，针对病理性钙信号的靶向治疗可能会成为抗恶性肿瘤侵袭迁移治疗的新思路。Intracellular calcium is one of the crucial signalings that modulate various physiological and pathological processes. Abnormal calcium signaling is closely associated with invasion and migration of neoplasms. Calcium regulates focal adhesion turnover, cytoskeletal reorganization and other processes about tumor cell movement through contacting with multiple downstream proteins, such as calpain, PYK2 and S100 protein family. Several calcium entry channels including store-operated calcium channels and transient receptor potential channels participate in the invasion and migration of tumor cells. Pathological calcium signaling may be a potential target in anti-invasion and anti-migration therapy.

关 键 词：钙信号 肿瘤侵润 肿瘤转移 

分 类 号：R730.2[医药卫生—肿瘤]