氟脲嘧啶持续输注为主的HLFP方案治疗晚期胃肠道癌的疗效观察  

Clinical Efficacy of CF／5－FU DDP 10－HCPT in Patients with Advanced Gastrointestinal Carcinoma

作　　者：吴晴[1] 丁红华[1] 陈栋晖[1] 朱莉菲[1] 邢红[1] 杨红欣 

机构地区：[1]上海市第一人民医院肿瘤科,上海市200080

出　　处：《中国肿瘤临床》2001年第2期138-140,共3页Chinese Journal of Clinical Oncology

摘　　要：目的：观察亚叶酸钙（CF）、氟脲嘧啶（5－FU）、顺铂（DDP）、10－羟基喜树碱（10－HCPT）（HLFP）方案治疗晚期胃肠道癌的效果。方法：采用HLFP联合化疗方案治疗晚期胃癌29例，肠癌18例。CF每天200mg／m2，静脉滴注，连用5天；5－FU每天375mg／m2；静脉持续滴注，连用5天；DDP 80mg／m2，分5天静脉滴注；10－HCPT每天6mg／m2，静脉滴注，连用5天，21天为一周期。结果：胃癌29例，完全缓解（CR）4例，部分缓解（PR）9例，总缓解率44．8％（13例）；肠癌18例，完全缓解（CR）1例，部分缓解（PR）5例，总缓解率30．0％（6例）。不良反应主要是消化道反应、口腔炎和骨髓抑制。结论：氟脲嘧啶持续输注为主的HLFP方案治疗晚期胃癌疗效较高，不良反应轻，可耐受，该方案治疗晚期肠癌疗效未见比CF／5－FU明显提高。Objective To evaluate the clinical efficacy of CF／5－FU DDP and 10－HCPT in patients with advanced gastrointestinal carcinoma． Methods A combined chemotherapy scheme of HLFP was used CF 200mg／m2／d iv f 5 days 5－FU 375mg／m2／d for 5 days by continuous infusion and 10－HCPT 6mg／m2／d iv for 5 days as well as DDP 80mg／m2 iv for 5 days． The above scheme was repeated every three weeks． Results Of 29 cases of gastric cancer 4 achieved CR and 12 PR the response rate CR＋PR was 44．8％． Of 18 cases of colorectal cancer One had CR and 5 PR and the response rate CR＋PR was 30．0％． The main toxic side effects included anorexia nausea vomiting stomatitis and leucopenia． Conclusion HLFP regimen has relatively high response rates in patients with advanced gastric carcinoma but not in colorectal carcinoma． The toxicity is slight and can be well tolerated．

关 键 词：胃肠肿瘤 亚叶酸钙 氟脲嘧啶 顺铂 10-羟基喜树碱 药物治疗 HLFP方案 

分 类 号：R730.5[医药卫生—肿瘤]