1-(3-巯基-2-甲基丙酰基)吡咯-2-羧酸的合成  

Synthesis of 1-(3-Mercapto-2-Methylpropionyl)-Pyrrolidine-2-Carboxylic Acid

作　　者：娄凤文[1] 刘晴晴[1] 花荣[1] 朱成章[1] 卞谋旺 刘清[1] 

机构地区：[1]淮阴师范学院化学化工学院,江苏淮安223000

出　　处：《淮阴师范学院学报（自然科学版）》2013年第4期315-317,322,共4页Journal of Huaiyin Teachers College;Natural Science Edition

摘　　要：碱性离子液体[bmim]OH能有效地促进硫代乙酸和甲基丙烯酸乙烯酯的迈克尔加成反应,反应在室温条件下进行,在30 min内可以取得定量收益率的2-甲基-3-乙酰硫基丙酸乙烯酯.以甲基丙烯酸乙烯酯为起始原料,提出了一种合成卡托普利的新方法.A novel protocol for the Michael addition of thiolacetic acid to methacrylic acid vinyl ester was devel-oped using a basic ionic liquid [bmim ]OH as catalyst and solvent ,the reaction was carried out at room temperature and could obtain good yields in 30 min .A new synthesis of active pharmaceutical ingredients named captopril ,the was achieved by Michael addition and N-acylation ,in high purity from methacrylic acid vinyl ester .

关 键 词：甲基丙烯酸乙烯酯 硫代乙酸 卡托普利 

分 类 号：O629[理学—有机化学]