FMMU白化豚鼠DNA指纹图研究初报  

Preliminary study of the DNA fingerprint of FMMU albino Guinea pig

作　　者：王洪涛[1] 顾为望[1] 高丽丽 

机构地区：[1]第一军医大学实验动物学教研室,广东广州510515 [2]广州花卉研究中心,广东广州510360

出　　处：《第一军医大学学报》2001年第2期143-145,共3页Journal of First Military Medical University

基　　金：广东省自然科学基金!(990389)

摘　　要：目的研究ＦＭＭＵ（第一军医大学的英文缩写）白化豚鼠遗传特性，为培育ＦＭＭＵ白化豚鼠提供依据和基础资 料。方法 以Ｍ１３ ｍｐ１８单链 ＤＮＡ为探针，对 ＦＭＭＵ白化豚鼠及普通花色豚鼠的 ＤＮＡ指纹图进行比较分析。结果 ＦＭＭＵ白化豚鼠同一个体不同组织的ＤＮＡ指纹图完全一致，其平均带数为２３．４，有品种特征带趋向，两个随机个体具 有完全相同ＤＮＡ指纹图概率为５．５ｘ１０－６。结论ＤＮＡ指纹图能准确反映ＦＭＭＵ白化豚鼠遗传变异度以及与花色豚鼠 的遗传差异。To provide basic information for breeding FMMU (abbreviation for First Mintary Medical University) albino guinea pig by studying its genetic characteristics. Methods DNA fingerprints of FMMU albino guinea pigs were analyzed and compared with that of the pigmented guinea-pigs generated by probe M13 mp18. Results The DNA fingerpring patterns obtained from different organs of the same individual of FMMU albino guinea pig were completely identical, with 23.4 bands on average, showing inclination for a new breed. The probability to have identical DNA fingerprints patterns between 2 randomly selected FIMMU guinea pigs was 5.5xl0-6. Conclusion DNA fingerprints can reflect genetic variability of FMMU albino guinea pigs and may be used to measure genetic distance from the pigmented guinea pigs with accuracy.

关 键 词：遗传特性 白化豚鼠 M13mp18DNA DNA指纹图谱 

分 类 号：R394[医药卫生—医学遗传学]