化疗对晚期食管癌患者细胞免疫及调节T细胞的影响  

Effect of Chemotherapy on Cellular Immune Function and Tregs in Patients with Advanced Esophageal Cancer

作　　者：廖娟[1] 周云峰[1] 

机构地区：[1]川北医学院附属医院,四川南充637000

出　　处：《现代临床医学》2014年第1期32-34,共3页Journal of Modern Clinical Medicine

摘　　要：目的:探讨晚期食管癌患者化疗前后细胞免疫及调节T细胞(tregs)的变化及其临床价值。方法:采用流式细胞术检测健康志愿者及食管癌患者化疗前后外周血CD4+T、CD8+T细胞及调节T细胞的比例变化。结果:晚期食管癌患者化疗前外周血CD4+T细胞所占比例和CD4+T/CD8+T均较化疗后低,且二者均低于健康对照组(P<0.05)。晚期食管癌患者CD4+CD25+T细胞和Tregs细胞所占比例化疗后较化疗前有所降低,二者均明显高于健康对照组。结论:化疗能明显减轻晚期食管癌患者的肿瘤免疫耐受,改善免疫状况。Objective： To investigate the changes of cellular immune function and CD4 ＋ CD25 ＋regulatory T cells （Tregs） in peripheral blood of patients with advanced esophageal cancer before and after chemotherapy and their clinical implications. Methods： The proportion of CD25 ＋ CD25＋ Tregs among CD4 ＋ T lymphocytes and the proportion of CD4 ＋ and CD8 ＋ T cells of PBMC in peripheral blood of 32 patients with advanced esophageal cancer were determined by flow cytometry before and after chemotherapy. Results： Compared with control group, the levels of CD4＋T lymphocytes and CD4＋/CD8＋ T lymphocytes were decreased in patients with advanced esophageal cancer before and after chemotherapy, but the data after treatment was higher than that before. The percentage of CD4 ＋CD25 ＋ T cells and Tregs among CD4 ＋ T lymphoeytes significantly changed after chemotherapy as compared with that before chemotherapy, the difference was significant between the patients and the healthy people . Conclusion：chemotherapy can improve the immune function of patients with advanced esophageal cancer.

关 键 词：免疫调节T细胞 食管癌 化疗 细胞免疫 

分 类 号：R735.1[医药卫生—肿瘤]