二苯乙烯低聚体对小鼠实验性肝损伤的影响  

EFFECT OF STILBENE POLYMER (Gn-3) ON EXPERIMENTAL LIVER INJURIES IN MICE

作　　者：侯艳宁[1] 朱秀媛[1] 梁晓莉[2] 程桂芳[1] 

机构地区：[1]中国医学科学院,中国协和医科大学药物研究所,北京100050 [2]解放军总后勤部高等医学专科学校,北京100070

出　　处：《药学学报》2001年第2期81-83,共3页Acta Pharmaceutica Sinica

摘　　要：目的　研究二苯乙烯低聚体 (Gn 3)对各种不同类型实验性肝损伤的影响。方法　用小鼠CCl4 、醋氨酚和免疫性肝损伤模型 ,以血清ALT水平 ,肝脏MDA和GSH含量 ,肝脏指数和光镜下组织病理变化为观测指标 ,观察Gn 3预防给药对肝损伤的影响。结果　Gn 3预防给药 3d可降低上述 3种类型肝损伤小鼠血清ALT水平、肝脏MDA含量 ,改善组织病理变化 ,但对肝脏GSH含量无显著影响。结论　Gn 3对AIM To study the protective effect of Gn 3 (a stilbene polymer isolated from Gnetum parvifolium ) against liver injury induced by CCl 4, N acetyl p aminophenol (APAP) and Bacillus Calmette Guerin (BCG) plus bacterial lipopolysaccharide (LPS) in mice. METHODS The experimental model of liver injury were induced by 0 1% CCl 4 ip (10 mL·kg -1 ·d -1 for 3d), APAP ip (150 mg·kg -1 ) or BCG (5 mg) plus LPS (7 5 μg) in mice. The levels of ALT in serum, MDA and GSH in liver tissues were detected. The histopathologic changes were observed by light microscope. RESULTS Gn 3 was shown to markedly reduce the elevated serum ALT levels, liver tissue MDA and improve the histopathological changes in all the three experimental liver injury models. No effect of Gn 3 was observed on the liver GSH level in liver injury mice. CONCLUSION Gn 3 was found to inhibit the development of liver injury caused by CCl 4, APAP, or BCG plus LPS. This means that Gn 3 has liver protective effects.

关 键 词：肝损伤 二苯乙烯低聚体 白三烯受体拮抗剂 小鼠 Gn-3 

分 类 号：R575[医药卫生—消化系统] R285.5[医药卫生—内科学]