围手术麻醉期输注氨基酸的研究进展  

Research progress of perioperative amino acid infusion

作　　者：付树英 葛圣金[1] 

机构地区：[1]复旦大学附属中山医院麻醉科,上海200032

出　　处：《国际麻醉学与复苏杂志》2014年第3期246-249,共4页International Journal of Anesthesiology and Resuscitation

摘　　要：背景围手术麻醉期的应激反应不利于患者的术后恢复，这与正在快速发展的快速康复外科（fasttracksurgery，FTS）理念相背离。营养支持是FTS的一个重要策略，输注氨基酸作为围手术麻醉期营养支持的有效方式已有较多临床和基础研究。目的探讨围手术麻醉期输注氨基酸对机体体温和营养物质代谢的影响。内容氨基酸通过其营养物热效应（nutrientinducedthermogenesis，NIT）为围手术麻醉期患者提供了保温作用，并通过多种途径抑制脂肪动员和蛋白分解，促进蛋白合成，但可能加速血糖的升高。趋向把握围手术麻醉期输注氨基酸的时机和剂量，使这一FTS的策略得到优化。Background The perioperative period stress response is not conducive to the patient＇s postoperative recovery. It goes against the fast track surgery （FYS）, which is rapidly developing recently. Nutritional support is an important strategy of FTS, and there are already many clinical and basic studies which confirm that perioperative amino acid infusion is an effective mean of nutritional support. Objective This review will discuss the influence of perioperative amino acids infusion to the body temperature and metabolism. Content Amino acid infusion alleviates hypothermia via nutrient induced thermogenesis （NIT）, and can inhibit fat mobilization and muscle protein breakdown, promote protein synthesis, while accelerate the increase of blood glucose concentration. Trend It is an optimical strategy for FTS to explore appropriate time and dose of perioperative amino acids infusion.

关 键 词：氨基酸 麻醉 围手术麻醉期 代谢 营养支持 快速康复外科 

分 类 号：R614[医药卫生—麻醉学]