原花青素对营养肥胖模型大鼠氧化应激的影响  

Effect of Grape Seed Procyanidins on Oxidative Stress in Diet-Induced Obese Rats

作　　者：肖俊松[1] 王莹[1] 宋雪琳[1] 吴华[2] 单静敏[1] 曹雁平[1] 

机构地区：[1]北京工商大学食品添加剂与配料北京高校工程研究中心食品风味化学北京重点实验室,北京100048 [2]江汉大学生命科学院,湖北武汉430058

出　　处：《食品科学》2014年第3期183-186,共4页Food Science

基　　金：国家自然科学基金项目(31201323);北京市自然科学基金项目(6123033);“十二五”国家科技支撑计划项目(2011BAD23B02)

摘　　要：以高脂饲料喂养Wistar大鼠建立营养肥胖模型,然后灌胃不同剂量葡萄籽原花青素4周,研究其对大鼠肥胖程度、氧化应激和炎症的影响。结果表明:与模型组相比,葡萄籽原花青素可显著降低肥胖大鼠体质量、肾周脂肪水平、肝脏湿质量、血清甘油三酯及血清总胆固醇水平,但对血清高密度脂蛋白和血清低密度脂蛋白水平无影响;葡萄籽原花青素可显著降低大鼠血清中丙二醛水平,升高超氧化物歧化酶和过氧化氢酶水平,但对谷胱甘肽过氧化物酶水平无影响;葡萄籽原花青素可降低白细胞介素-1的水平,且与原花青素剂量相关;对内毒素以及肿瘤坏死因子-α的水平无显著影响,但可显著恢复由高脂膳食导致的异常高的肠道壁通透性。Nutritional obesity model was induced by feeding Wistar rats with a high-fat diet. The model rats were treated with different dose of grape seed procyanidins by gavage for 4 weeks. The effect of grape seed procyanidins on obesity, oxidative stress and inflammation was investigated in these model rats. The results showed that grape seed procyanidins significantly decreased body weight, perinephrit fat weight and liver weight. Grape seed procyanidins could also decrease the levels of triglyceride and total cholesterol in serum, but no effect on high-density lipoprotein or low-density lipoprotein was observed. It also exhibited a decrease of malonaldehyde level in rat serum and an increase in the levels of superoxidase and catalase, but no effect on glutathione peroxidase was observed. The effect of grape seed procyanidins on the levels of TNF-α, IL-1, IL-6 and endotoxin was not significant. Grape seed procyanidins could significantly restore the abnormally high intestinal permeability caused by high-fat diet.

关 键 词：葡萄籽原花青素 肥胖 氧化应激 炎症因子 

分 类 号：Q959.837[生物学—动物学]