丙戊酸钠对癫痫患儿体重及神经肽Y的影响  

Effect of Valproic Acid Treatment on Body Weight and Neuropeptide Y in Pediatric Patients with Epilepsy

作　　者：何晓英[1] 付华[2] 刘永刚[1] 李小刚[1] 

机构地区：[1]泸州医学院附属医院神经内科,四川省泸州市646000 [2]泸州医学院附属医院乳腺外科,四川省泸州市646000

出　　处：《医学理论与实践》2014年第3期281-282,300,共3页The Journal of Medical Theory and Practice

摘　　要：目的:探讨丙戊酸钠(VPA)对癫痫患儿体重及神经肽Y(NPY)的影响。方法:按照纳入标准收集我院神经内科门诊2011年5月-2013年5月首次诊断癫痫后VPA单药治疗的患儿48例作为实验组,于治疗前、治疗后1、3、6个月检测患儿体质量指数(BMI)及血清NPY水平,分析两者之间的关系。另选择健康儿童24例作为对照组。结果:实验组治疗后1、3、6个月BMI及血清NPY均呈现出上升趋势,且两者在各时间点均明显高于对照组,差异具有统计学意义(P<0.05)。结论:VPA能够使癫痫患儿血清NPY水平升高,导致患儿体重增加。Objective.To study the effect of valproic acid on body weight and serum neuropeptide Y level in pediatric patients with epilepsy. Methods：48 pediatric patients with epilepsy in experiment group who were selected according to the standard of selection during May 2011 to May 2013 were treated with VPA for 6 months. The parameters of body mass index（BMI） and serum neuropeptlde Y levels were detected before treatment and 1,3,6 months after treatment, then investigated the association between them. 24 healthy children were divided into the control group. Results.. At 1,3, 6 months after treatment in experiment group BMI and the serum neuropeptide Y both showed uptrend, which were significantly higher than those of their control group at the same time point （P〈0. 05）. Conclusion.. The serum neuropeptide Y level was increased after valproic acid treatment,which led the body weight of pediatric patients with epilepsy to increase.

关 键 词：丙戊酸钠 癫痫 神经肽Y 

分 类 号：R742.1[医药卫生—神经病学与精神病学]