中药三七与桑葚抗氧化作用的对比研究  

Comparative study on the antioxidation effect of Panax notoginseng and Mulberry

作　　者：李彦彬[1] 邓秀婷 罗姮[1] 徐远超[1] 杨高群[1] 林秀澄 李朝敢[1] 

机构地区：[1]右江民族医学院,广西百色533000

出　　处：《现代中西医结合杂志》2014年第8期822-823,共2页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的观察相同剂量中药三七混悬液和桑葚提取液对D-半乳糖致衰老小鼠SOD、GSH-Px活性和MDA含量的影响。方法用D-半乳糖建立小鼠衰老模型,同时实验组分别灌胃给予相同剂量2.0 g/(kg·d)的三七混悬液和桑葚提取液。给药40 d后处死小鼠,取血清及肝脏测定超氧化物歧化酶(SOD)、谷胱甘肽-过氧化物酶(GSH-Px)活性和丙二醛(MDA)含量。结果三七混悬液和桑葚提取液均可以提高小鼠血清和肝脏中SOD、GSH-Px活性和降低MDA含量(P<0.01或0.05),相比之下,桑葚提取液在GXH-Px上的效果较明显,而三七混悬液则在SOD上的作用更明显。结论桑葚提取液和三七混悬液都具有抗氧化、抗衰老作用。Objective It is to observe the effect of the same dose between panax notoginseng and mulberry on SOD, GSH - Px activity and MDA content of aging mice induced by D - galactose. Methods The aging model mice was established by subcutaneous injection of D - galactose on the back and the mice in experimental group were respectively given the same dose （ 2.0 g/（ kg · d） of panax notoginseng mixed suspension and mulberry extract at the same time. After 40 days, the mice were killed and the SOD,GSH - Px activity as well as content of MDA in serum and liver were measured. Results Both of panax notogineng mixed suspension and mulberry extract could improve activity of SOD and GSH - Px and reduce MDA content in serum and liver of mice （ P 〈 0.01 or 0.05 ） , by contrast, mulberry extract effect on GSH - Px was obvious, while panax notogin- seng mixed suspension had more apparent effect on SOD. Conclusion Panax notoginseng and mulberry both have antioxidant and anti-aging functions.

关 键 词：桑葚提取液 三七混悬液 D-半乳糖 抗氧化 抗衰老 

分 类 号：R-332[医药卫生]