原发性肝癌切除术后保肝药联合应用与肝功能恢复相关性研究  

Research on the relationship between surgical treatment combined with drug therapy and the recovery of hepatic function following tumor resection of primary liver cancer

作　　者：金柔男[1] 龚纯贵[1] 战旗[1] 姜云霞[1] 陈安妮[1] 李捷玮[1] 

机构地区：[1]第二军医大学附属东方肝胆外科医院药材科,上海201208

出　　处：《海军医学杂志》2014年第1期9-12,共4页Journal of Navy Medicine

摘　　要：目的探讨原发性肝癌(primary liver cancer,PLC)切除术后保肝药联合应用与肝功能恢复之间的相关性,为临床治疗提供合理建议。方法选取我院2009年1月至2010年12月诊断为PLC并行肝脏肿瘤切除术的病历120份进行回顾性分析,记录齐全能够进行有效分析的为83例。依据《中国国家处方集》(2010)和药物作用机制将保肝药分为6类:A=抗炎类,B=稳定膜系统类,C=结合解毒类,D=改善供能类,E=促进再生类,F=其他类。结果 (1)A+D治疗方案与C+D治疗方案比较,总胆红素k值的P=0.046,门冬氨酸氨基转移酶k值的P=0.035,C+D治疗方案优于A+D方案;(2)总胆红素的k值与门冬氨酸氨基转移酶的k值存在正相关,P<0.01;(3)总胆红素k值和门冬氨酸氨基转移酶的k值与肝门阻断时间、肝硬化类型等因素不相关。结论原发性肝癌行肝脏肿瘤切除术后,C+D治疗方案比A+D治疗方案更能促进肝功能的恢复。Objective To explore the relationship between surgical treatment combined with drug therapy and the recovery of hepatic function following tumor resection of primary liver cancer （ PLC） , and to provide reasonable recommendations for clinical treat-ment of the disease .Methods One hundred and twenty cases , which were diagnosed as primary liver cancer and given tumor resection from January 2009 to December 2010 in our hospital were selected and analyzed retrospectively .There were 82 cases that had complete records and could be used for effective analysis .Based on ＆quot;the China National Formulary＆quot;（2010） and the mechanism of drugs , hepa-to-protectants were divided into 6 categories：⑴A=anti-inflammatory drug , B=membrane system stabilizing drug , C=combined de-toxification drug, D=enhanced energy supply drug, E=regeneration promotion drug and F =the category of other drugs.Results （1） When the A＋D treatment profile was compared with the C ＋D treatment profile, the k value of total bilirubin （TB） was P=0.046 and the k value of aspartate aminotransferase （AST） was P=0.035.The C＋D treatment profile was superior to that of the A ＋D treatment profile.（2） Positive correlation could be noted between the k values of ALT and AST （P＆lt;0.01）.（3） The k value of TB and AST were negatively correlated with the blocking time of portal vein , cirrhosis type and other variables .Conclusion After tumor resection of the primary liver cancer , the C ＋D treatment profile was superior to the A ＋D treatment profile in enhancing recovery of hepatic function .

关 键 词：原发性肝癌 保肝药 肝功能 

分 类 号：R735.7[医药卫生—肿瘤]