奥卡西平治疗儿童癫痫部分性发作的临床效果分析  

Therapeutic effects of oxcarbazepine in children with partial seizures of epilepsy

作　　者：王锋[1] 于静[1] 

机构地区：[1]新疆维吾尔自治区人民医院儿科,乌鲁木齐830000

出　　处：《检验医学与临床》2014年第4期450-452,共3页Laboratory Medicine and Clinic

摘　　要：目的：探讨奥卡西平治疗儿童癫痫部分性发作的临床效果。方法采用随机数字表法将2011年2月至2012年2月于本院治疗的癫痫部分性发作患儿49例分为治疗组（24例）和对照组（25例），治疗组采用奥卡西平口服片剂治疗，对照组采用复方丙戊酸钠口服溶液治疗；随访时间为1年，观察患儿的癫痫发作频率，以及血常规、尿常规、肝肾功能及心电图检查结果的变化，并对治疗效果及患儿智力情况进行分析。结果治疗组治疗1年后共失访3例，对照组治疗后共失访4例。随访1年后，治疗组患儿的显效率、有效率均低于对照组，但两组患儿的临床疗效比较差异无统计学意义（P＞0．05）。治疗组患儿分类、填图、译码得分明显高于对照组（P＜0．05），但算数、领悟、知识、背数、言语智商、操作智商、总智商得分组间比较差异无统计学意义（P＞0．05）。治疗组发生不良反应共4例，在治疗1～2周后自行消失。两组患儿的不良反应发生率比较差异无统计学意义（P＞0．05）。结论奥卡西平治疗儿童癫痫部分性发作对患儿的认知能力无明显影响，患儿治疗依从性较好，疗效确切，安全可靠，是一种较为理想的儿童癫痫治疗药物。Objective To evaluate the therapeutic effects of oxcarbazepine in children with partial seizures of epilepsy.Methods According to random digits table,a total of 49 children with partial seizures of epilepsy were di-vided into treatment group （n=24）and control group （n=25）.Treatment group was treated with oxcarbazepine o-ral tablet,and control group was treated with valproic acid compound sodium oral solution.Within the follow-up time of 1 year,seizure frequency was observed,blood,urine,liver and kidney function and electrocardiogram detection were performed,and effects and intellectual analysis were also performed.Results After 1 year of treatment,3 cases in treatment group and four cases in control group were lost to follow-up.After 1 year of treatment,the ratio of excel-lence and effectiveness in treatment group were lower than control group,but without statistical difference between the two groups （P＆gt;0.05）.Scores of classification,mapping an d decoding in treatment group were significantly higher （P＆lt;0.05）,but the differences of scores of arithmetic,understanding,knowledge,number remember,verbal intelligence quotient,performance intelligence quotient and full intelligence quotient between the two groups were not significant （P＆gt;0.05）.In treatment group,there were four cases with adverse reactions,which disappeared in 1 to 2 weeks after treatment.The incidence of adverse reactions was not significantly different between the two groups （P＆gt;0.05）.Conclusion Oxcarbazepine treatment for partial seizures of epilepsy in children might not influence the cognitive abilities,which could be with fine efficacy,safety and reliability.And children could be with fine treatment compliance.Oxcarbazepine could be an ideal treatment drug for epilepsy in children.

关 键 词：奥卡西平 儿童 癫痫 部分性发作 认知功能 

分 类 号：R742.1[医药卫生—神经病学与精神病学]