Synthesis, Structure and Antimicrobial Activity of 2-Phenyl-4H-spiro[benzo[e][1,4,2]oxaza- phosphinine-3,3′-indolin]-2′-one 2-oxide  

作　　者：刘仁蝶 孔杜林 吴明书 李高楠 李国柱 

机构地区：[1]Key Laboratory of Tropical Medicinal Plant Chemistry of the Ministry of Education, College of Chemistry & Chemical Engineering, Hainan Normal University [2]School of Pharmaceutical Sciences, Hainan Medical University

出　　处：《Chinese Journal of Structural Chemistry》2014年第2期204-208,共5页结构化学（英文）

基　　金：Project supported by the National Natural Science Foundation of China(No.21162008)

摘　　要：A novel spiro-compound（C20 H15 N2 O3 P） has been synthesized and characterized by means of IR and 1H NMR. Its crystal structure was determined by X-ray diffractometry. The crystal belongs to the monoclinic system, space group P21 /c with a = 9.1628（7）, b = 12.9490（7）, c = 15.7898（11）, β = 103.952（8）o, Mr = 36.08, V = 1818.2（2）3, Z = 4, Dc = 1.382 g/cm3, F（000） = 788, μ = 0.179 mm-1, R = 0.0701 and wR = 0.1513. The preliminary biological test showed that the title compound has activities against Escherichia coli, S.albus, Bacillus subtilis, Staphylocc- ocusaureus and Micrococcus tetragenus with MIC to be 0.038, 0.038, 0.075, 2.48, and 0.15 mg/mL, respectively.A novel spiro-compound（C20 H15 N2 O3 P） has been synthesized and characterized by means of IR and 1H NMR. Its crystal structure was determined by X-ray diffractometry. The crystal belongs to the monoclinic system, space group P21 /c with a = 9.1628（7）, b = 12.9490（7）, c = 15.7898（11）, β = 103.952（8）o, Mr = 36.08, V = 1818.2（2）3, Z = 4, Dc = 1.382 g/cm3, F（000） = 788, μ = 0.179 mm-1, R = 0.0701 and wR = 0.1513. The preliminary biological test showed that the title compound has activities against Escherichia coli, S.albus, Bacillus subtilis, Staphylocc- ocusaureus and Micrococcus tetragenus with MIC to be 0.038, 0.038, 0.075, 2.48, and 0.15 mg/mL, respectively.

关 键 词：SYNTHESIS crystal structure HETEROCYCLE SPIROCYCLIC 

分 类 号：O626.1[理学—有机化学]