血清Tg检测联合^(131)I-WBS在DTC术后的临床价值  

Clinical Value of Combined Detection of Serum Tg and ^(131)I-WBS in Postoperative of Patients with DTC

作　　者：王治国[1] 张文文[1] 郝珊瑚[1] 张彤[1] 张国旭[1] 

机构地区：[1]沈阳军区总医院核医学科,辽宁沈阳110840

出　　处：《标记免疫分析与临床》2014年第1期22-25,共4页Labeled Immunoassays and Clinical Medicine

摘　　要：目的探讨分化型甲状腺癌(DTC)甲状腺清除术后血清甲状腺球蛋白(Tg)联合131I全身显像(131I-WBS),为判定甲状腺癌的复发及转移提供参考依据。方法 56例DTC患者,甲状腺全切或次全切术后4~6周,均行131I清除残余甲状腺治疗,3~6个月后重复治疗,治疗前停用甲状腺激素3~6周,同时忌碘饮食,治疗中检测血清Tg和口服碘化钠(131I)治疗剂量3.70~7.40 GBq后5~7天行131I-WBS。结果在首次清除残留甲状腺组织治疗时,显像发现淋巴结、肺及骨转移8例,其余转移灶于3~6个月后二次治疗时发现,有11例DTC患者(19.6%)Tg测定在正常范围,而131I-WBS出现转移灶;有7例患者(12.5%)Tg测定异常,而131I-WBS正常。结论 Tg测定和131I-WBS可作为诊断DTC术后复发及转移的重要指标,二者应联合应用、互相补充,具有重要的临床价值。Objective To investigate explore clinical value of combined detection of serum Tg with 131iwhole body seintigraphy （J3L I-WBS） in patients with differentiated thyroid carcinoma （DTC）. Methods 56 cases of DTC patients who total thyroidectomy or subtotal after 4 to 6 weeks were underwent removal of residual thyroid 131I therapy and repeated treatment for 3 to 6 months. The serum Tg levels were detected and 131I-WBS were performed. Results After first time removing residual thyroid tissue therapy, the t31I-WBS imaging found the lymphnodes, lung and bone metastases in 8 cases, the other metastases lesions were found in the rest of the secondary treatment for 3 to 6 months. The serum Tg levels in 11 patients （ 19.6% ） were in normal range, while the 1311-WBS appeared to have metastases lesions. 7 patients （12.5%） with abnormal Tg levels showed normal 131 I-WBS. Conclusion The serum Tg and 131I-WBS can be used as important indicators in diagnosis of DTC recmTence and metastasis. The combined detection of two methods should have important clinical value to improve the diagnostic accuracy.

关 键 词：分化型甲状腺癌 复发 转移 甲状腺球蛋白 131I全身显像 

分 类 号：R736.1[医药卫生—肿瘤]