原发性肺类癌患者的临床特征和预后研究  

Clinical Characteristics and Prognostic Factors of Primary Pulmonary Carcinoid Tumors

作　　者：刘广杰[1] 刘庆熠[1] 解少男 孟宪利[1] 王洪琰[1] 卢永昌[1] 

机构地区：[1]河北医科大学第四医院胸外科,河北省石家庄市050011

出　　处：《中国全科医学》2014年第1期34-38,共5页Chinese General Practice

摘　　要：目的探讨原发性肺类癌患者的临床特征,了解影响其预后的关键因素。方法回顾性分析河北医科大学第四医院2002年5月—2012年5月经手术切除及术后病理确诊的31例原发性肺类癌患者的临床资料。对性别、年龄、吸烟史、肿瘤位置、肿瘤大小、淋巴结转移、病理类型、临床病理分期及术后辅助治疗情况与预后的关系进行统计学分析。结果全部患者的1年、3年、5年生存率分别为90.3%(28/31)、67.7%(21/31)及54.8%(17/31)。典型类癌、非典型类癌的5年生存率分别为78.6%(11/14)和35.3%(6/17)。淋巴结转移组和无淋巴结转移组的5年生存率分别为28.6%(2/7)和58.3%(14/24)。单因素分析显示病理类型、病理分期、肿瘤大小、淋巴结转移是预后的可能影响因素。多因素分析显示,病理类型(b=1.711)和临床病理分期(b=1.928)是预后的独立影响因素。结论原发性肺类癌的恶性程度较低,病理类型及病理分期是预后的独立影响因素,典型类癌的预后好于非典型类癌。Objective To investigate the clinical characteristics and prognostic factors of primary pulmonary carcinoid tumors （PPCT） through a retrospective analysis. Methods Clinical records of 31 patients with PPCT undergoing thoracic surgery in the Surgery Department of Hebei Medical University Affiliated Fourth Hospital between May 2002 and May 2012 were reviewed, and the prognostic value was analyzed for various factors including sex, age, smoking history, tumor location, tumor size, lymph node metastasis, histological type, pathological staging and adjuvant treatment regimen. Results In the 31 patients analyzed, 1-year, 3-year, and5-yearsurvivalrateswere90.3% （28/31）,67.7% （21131） and 54. 8% （17/31） respectively. The 5 year survival rate of typical carcinoid, atypical carcinoid tumor were 78. 6% （11/14） and 35. 3% （6/17） . 5 year survival rates were 28.6% （2/7） and 58.3% （14/24） in lymph node metastasis group and no lymph nodemetastasis group. Univariate analyses showed that the pathological type, pathological TNM stage, tumor size, presence or absence of lymph node metastasis were the major factors influencing the prognosis. Multivariate analyses revealed that tumor pathological type （b = 1. 711） and pathology TNM staging （b = 1. 928） were independent prognostic factors of PPCT. Conclusion Patients with PPCT have a higher survival rate than patients with other types of lung cancer following surgical treatment. Pathological type and stage are independent prognostic factors of PPCT.

关 键 词：肺肿瘤 原发性肺类癌 典型类癌 非典型类癌 预后 神经内分泌肿瘤 

分 类 号：R734.2[医药卫生—肿瘤]