代谢综合征组分与消化性溃疡的关系研究  

Relationship of Metabolic Syndrome Components to Peptic Ulcer Disease

作　　者：李娟[1] 翟淑娜[2] 姜腾轩[2] 李岩[2] 韩彬[3] 卢智泉[2] 

机构地区：[1]辽宁医学院附属第三医院消化科,辽宁省锦州市121000 [2]辽宁医学院流行病学教研室 [3]辽宁医学院附属第一医院

出　　处：《中国全科医学》2014年第2期134-137,共4页Chinese General Practice

摘　　要：目的探讨代谢综合征组分与消化性溃疡(PUD)的关系。方法选择2010年10月—2012年5月在当地3所三级甲等医院经内镜或X线钡餐检查确诊为PUD的256例患者(病例组)及同期未患PUD的256例对照者(对照组)。采用自行设计的调查表进行调查,内容包括一般情况、生活方式、既往史及实验室检查等。对每项代谢综合征组分与PUD的关系进行单因素分析和多因素Logistic回归分析。结果在单因素分析的基础上进行多因素Logistic回归分析,结果显示年龄≤45岁腰围(WC)>85 cm男性和年龄>45岁WC>80 cm女性较对照者发生PUD的危险性均增加〔OR=2.869,95%CI(1.245,2.546);OR=2.402,95%CI(1.623,3.154)〕;高密度脂蛋白胆固醇(HDL-C)降低、收缩压和空腹血糖升高者较对照者发生PUD的危险性增加〔OR=2.702,95%CI(1.630,4.477);OR=1.657,95%CI(1.116,2.462);OR=2.485,95%CI(1.559,3.963)〕,对年龄进行分层后结果未发生变化。结论代谢综合征组分中WC增加、HDL-C降低及收缩压、血糖的升高均能增加PUD的危险性。Objective To investigate the association between metabolic syndrome （MS） components and the risk of peptic ulcer disease （PUD）. Methods A hospital - based case - control study was conducted in 256 PUD patients （ study group）, 256 non- PUD subjects （control group）. Univariate and multivariate Logistic regression analyses were performed on every components of metabolic syndrome. Results By multivariate Logistic regression analysis based on univariate analysis, the risk of PUD was higher in males aged ~〈45 years, WC 〉 85 cm and females aged 〉 45 years, WC 〉 80 cm than in control group ~OR=2.869, 95%CI （1.245, 2.546）; OR =2.402, 95%C1 （1.623, 3. 154）], and higher in patients with reduced HDL-C, increased SBP and FBG than in control group [OR=2.702, 95%CI （1.630, 4. 477）; OR = 1. 657, 95%CI （ 1.116, 2. 462） ; OR =2. 485, 95% CI （ 1. 559, 3. 963） ]. The results did not change after age stratification. Conclusion WC, HDL - C, SBP, hyperglycemia can increase the risk of PUD.

关 键 词：代谢综合征X 消化性溃疡 胆固醇 HDL 血压 腰围 

分 类 号：R573.1[医药卫生—消化系统] R589[医药卫生—内科学]