A New Hasubanan Alkaloid from Stephania hernandifolia  

作　　者：Lu-lu Deng Li-jia Tang Huan-yu Guan Li He Jian-xin Zhang Jian-hua Liu Xiao-jiang Hao Yuan-hu Zhang 

机构地区：[1]School of Chemistry and Material Science, Guizhou Normal University [2]The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences

出　　处：《Chinese Herbal Medicines》2014年第1期70-72,共3页中草药（英文版）

基　　金：Science and Technology Commission of China(2012CB722601);Science and Technology Department of Guizhou Province(QKHZYZ[2011]5085)

摘　　要：Objective To study the chemical constituents of Stephania hernandifolia. Methods Various chromato- graphic techniques were used to isolate the constituents, and the structures were elucidated on the basis of HR-EI-MS, 1D-NMR and 2D-NMR spectral analyses. Results A hasubanan alkaloid, hernsubanine D （1） was isolated from the whole plants of S. hernandifolia. The compound was screened for the cytotoxic activity against two human cancer cell lines in vitro. Conclusion Compound 1 is a new compound without cytotoxicity against A549 and K562 cells.Objective To study the chemical constituents of Stephania hernandifolia. Methods Various chromato- graphic techniques were used to isolate the constituents, and the structures were elucidated on the basis of HR-EI-MS, 1D-NMR and 2D-NMR spectral analyses. Results A hasubanan alkaloid, hernsubanine D （1） was isolated from the whole plants of S. hernandifolia. The compound was screened for the cytotoxic activity against two human cancer cell lines in vitro. Conclusion Compound 1 is a new compound without cytotoxicity against A549 and K562 cells.

关 键 词：CYTOTOXICITY hasubanan alkaloid hernsubanine D MENISPERMACEAE Stephaniahernandifolia 

分 类 号：S567.9[农业科学—中草药栽培]