γ-分泌酶、淀粉样前体蛋白和早老蛋白1在阿尔采末病中相关性的研究进展  

Research progress on interactions among γ-secretase,amyloid precusor protein and presenilin-1 in Alzheimer's disease

作　　者：韦云[1] 刘剑刚[1] 李浩[1] 唐旭东[1] 

机构地区：[1]中国中医科学院西苑医院老年病科,北京100091

出　　处：《中国药理学通报》2014年第2期167-169,共3页Chinese Pharmacological Bulletin

基　　金：国家科技重大专项"重大新药创制"项目(No 2009ZX09103-391);国家自然科学基金资助项目(No 81173383)

摘　　要：阿尔采末病近年来发病率逐渐升高,对其发病机制的研究逐步深入。APP、PS1为已被明确的痴呆基因,γ-分泌酶是生成Aβ的限速酶,三者都是目前AD领域研究的热点,但是三者在AD间的具体相互作用机制及过程迄今还尚未明确,这些都可能是发现AD治疗新途径的潜在位点。The incidence of Alzheimer＇s disease（AD） has grad- ually risen in recent years and the researches on mechanism of AD have gradually become deeper. APP and PS are the identi-fied genetic triggers that lead to AD, and gamma secretase is the key enzyme which produces Aβ. All three are the hotspots of re-search about AD. The three are obviously interrelated, but theinteractions among these three still remain unknown. Those are potential therapeutic sites to develop a new therapeutic approach of AD.

关 键 词：阿尔采末病  γ-分泌酶 淀粉样前体蛋白 早老蛋白1 Β淀粉样蛋白 实验研究 

分 类 号：R-05[医药卫生] R745.7