立体定向自体骨髓基质干细胞移植治疗出血性脑卒中后遗症的临床观察  

The clinical observation in the treatment of sequelae hemorrhagic stroke of application stereotactic transplantation of autologous bone marrow stromal stem cell transplantation

作　　者：张小广[1] 王华[1] 方树民[1] 何承[1] 

机构地区：[1]河南大学第一附属医院,开封475001

出　　处：《中国医疗前沿》2013年第23期88-88,70,共2页China Healthcare Innovation

基　　金：2011年河南省医学科技攻关计划项目(编号:2011020110)

摘　　要：目的探讨自体骨髓基质干细胞移植治疗出血性脑卒中后遗症的临床疗效。方法对2011年1月-2012年6月20例出血性脑卒中患者采用立体定向技术进行自体骨髓基质干细胞移植术,于术前、术后1月、6月应用功能独立性测量(FIM)和神经功能缺损评分进行功能性评分。结果患者术后6个月内临床症状好转有效率达85%,无严重并发症出现。手术治疗1个月和6个月后FIM评分、神经功能缺损评分与治疗前相比明显升高,差异有统计学意义(P<0.05),且随随访时间增加评分改善更明显。结论自体骨髓基质干细胞移植治疗可改善出血性脑卒中患者后遗症,对于提高患者运动功能和生活质量有一定帮助,但其长期疗效仍需大样本多中心的临床研究进一步观察。Objective To investigate clinical effect of hemorrhagic cerebral apoplexy sequela treated with the application of autologous bone marrow stem ceils transplantation. Methods 20 cases patients with hemorrhagic from 2011 January to 2012 June were treated with stereotactic technique for autologous bone marrow stem cell transplantation. The functional independence measure（FIM） functional score, NIHSS were evaluated before operation, lmonth after operation and 6th month after operation. Results The clinical symptoms of patients with hemorrhagic stroke improved effective rate as to 85% whom without severe complications ~ surgical treatment for 1 month and 6 months later, FIM score and NIHSS were increased significantly compared with before treatment（P〈0.05）, with the more increase of follow-up time, the improvement is more obvious. Conclusion The autologous bone marrow stem cell transplantation therapy can improve the patients of hemorrhage sequelae stroke, motor function, the quality of life, but the clinical research on the long-term effects still needs a large sample multicenter further observation.

关 键 词：自体骨髓基质干细胞 干细胞移植 出血性脑卒中后遗症 

分 类 号：R743.3[医药卫生—神经病学与精神病学]