肿瘤光动力疗法——作用机制  

The Mechanisms of Photodynamic Therapy for Tumor : A Review

作　　者：李亚楠[1] 王怡乔[1] 潘铁成[1] 程才[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院心脏大血管外科,武汉市430030

出　　处：《中国激光医学杂志》2014年第1期39-48,共10页Chinese Journal of Laser Medicine & Surgery

基　　金：国家自然科学基金青年科学基金(81201751)

摘　　要：肿瘤光动力疗法(Photodynamic therapy,PDT)是一种应用于实体肿瘤治疗的新方法。机体被施予光敏剂后,再用特定波长的光照射,光敏剂随之活化,与底物及氧分子作用产生单线态氧及其他活性氧物质,可以直接杀伤肿瘤细胞。此外,其他作用如血管损伤、诱发炎症反应、促进抗肿瘤免疫等亦可导致肿瘤细胞死亡。本文综述了光动力疗法在肿瘤治疗方面的作用及其机制。Photodynamic therapy （PDT） is a therapeutic modality used for the treatment of solid tumors involving the administration of photo- sensitizing agent, followed by activation of the photesensitizer by light with a specific wavelength. Most of the effects of thistherapy re- sult from direct action of singlet oxygen and reactive oxygen species. However, increasing evidence indicates that anti-tumor effects are also mediated by the vascular effects , inflammation , anti-tumor immunity, etc. In this review, we summarizes the anti-tumor effects of PDT and their underline mechanisms.

关 键 词：光动力疗法 肿瘤 血管封闭 炎症反应 抗肿瘤免疫 

分 类 号：R730.5[医药卫生—肿瘤]