沈阳地区76例非何杰金淋巴瘤的分类及其免疫表型病理分析  

Classification and Pathological Analysis of Immunophenotype of 76 Cases of Non-Hodgkin Lymphoma in Shenyang

作　　者：贺慧颖[1] 贾心善[1] 郭毅[1] 

机构地区：[1]中国医科大学基础医学院分子病理学研究室,沈阳110001

出　　处：《中国医科大学学报》2001年第1期1-3,共3页Journal of China Medical University

摘　　要：目的 :探讨我国沈阳地区非何杰金淋巴瘤 (NHL)的病理特点及免疫组化表型分析。方法 :对 76例 NHL按照 WHO新分类进行病理观察和 10种抗体免疫表型测定。结果 :B系占 78.9% ,其中弥漫性大 B细胞淋巴瘤(DL BL)最多 ;其次为 MAL T型 (+/-单核细胞样 B细胞 )及淋巴浆细胞性淋巴瘤 (L PL)。T系占 2 1.1% ,以外周T非特殊型最多。CD79a对 B- NHL 染色阳性率达 10 0 % ,未见与 T细胞的交叉反应。CD3对 T- NHL 染色阳性率为88% ,与 B细胞仅有 5 %的交叉反应。结论 :我国沈阳地区 NHL 以 DL BL 和外周 T非特殊型为最多见 ,结内单核 B和淋巴浆细胞性比例较高。 CD79a和 CD3分别是具有高度敏感性和特异性的 B。Objective: Our aim was to discuss the pathological characteristics and immunophenotype of non Hodgkin lymphoma (NHL) in Shenyang. Methods: Histopathological observation was performed with immunohistochemical methods (SP method). We used 10 antibodies as B,T markers to analyze 76 cases of NHL according to the new WHO classification. Results: The B NHL was more prevalent than the T NHL. In B NHL, the Diffuse Large B cell Lymphoma (DLBL) was the most common, next was the mucosa associated lymphoid tissue lymphoma (+/-monocytoid B cells) and lymphoplasmacytic lymphoma (LPL). In T NHL, the peripheral T cell lymphoma unspecificly accounted most. The positivity rates of CD 79 a in B NHL were 100% and its cross reactivity was 0. The straining rates of polyclonal CD 3 with T cell were 88% and CD 3 only reacted with 5% of B NHL. Conclusion: The NHL in Shenyang was marked by the most common DLBL and peripheral T cell lymphoma, unspecificly. The rates of monocytoid lymphoma and LPL were higher. The CD 79 a and CD 3 were antibodies of B cell and T cell markers with high sensitivity and specificity, respectively.

关 键 词：非何杰金淋巴瘤 分类 免疫表型 病理分析 

分 类 号：R733.1[医药卫生—肿瘤] R730.231[医药卫生—临床医学]