“毒损脑络”病机假说的形成及其理论与实践意义  

The Hypothesis of the Injury of Brain Collaterals by Toxins and Its Theoretical and Practical Significance

作　　者：李澎涛[1] 王永炎[2] 黄启福[1] 

机构地区：[1]北京中医药大学病理教研室,北京100029 [2]中国中医研究院,北京100700

出　　处：《北京中医药大学学报》2001年第1期1-6,共6页Journal of Beijing University of Traditional Chinese Medicine

基　　金：国家"973"项目课题!(No.G19990 5 44 0 4) ;国家自然科学基金课题! (No .39970 937) ;中国博士后科学基金资助项目!(中博基 1998-

摘　　要：脑络瘀阻导致营卫失和 ,卫气壅滞而化生火毒进一步损伤脑络是中风病康复困难的病机关键。其现代病理学基础是中风发病过程中的缺血级连反应 ,即自由基、代谢毒性物质及兴奋性氨基酸等对微血管内皮细胞和神经细胞的损伤。在治疗上宜解毒通络、调和营卫。解毒以祛除损害因素 ,通络以畅通气血的渗灌 ,是中风病治疗的核心环节。从而阻抑脑缺血级连反应的损伤 ,调动机体自身的修复能力 ,作用于中风病的早期和恢复期的多个环节。The authors of this paper have put forward a hypothesis of the injury of brain collaterals by toxins. According to this hypothesis, the basic reason of the difficulty of apoplectic rehabilitation is that the brain collaterals are injured by the toxins of fire produced by the disharmony of ying and wei, and wei qi stagnation caused by the obstruction of brain collaterals. The authors hold that the modern pathological basis of the difficulty of apoplectic rehabilitation is the cerebral ischemic cascade in the apoplectic development, namely, the damage caused by free radicals, metabolic toxins and excitatory amino acids and so on, to the microvascular endothelial cells and nerve cells. The key points of the treatment of apoplexy, according to the authors, are to dispel the toxins and dredge brain collaterals, and to harmonize the relations between ying and wei. By doing these, the damage caused by cerebral ischemic cascade can be halted, and the repairing ability of the body can be mobilized. These effects can be seen in many aspects at the early stage and rehabilitating stage of apoplexy.

关 键 词：毒损脑络 病机 解毒通络 治法 中风 

分 类 号：R228[医药卫生—中医基础理论] R255.2[医药卫生—中医学]