microRNA在中医药防治非酒精性脂肪性肝病中的应用  

Application of microRNA in prevention and treatment of nonalcoholic fatty liver disease with traditional Chinese medicine

作　　者：孟胜喜[1] 胡义扬[1,2,3] 冯琴[1] 

机构地区：[1]上海中医药大学附属曙光医院肝病研究所,上海201203 [2]上海市高校中医内科学E-研究院,上海201203 [3]上海市中医临床重点实验室,上海201203

出　　处：《中华中医药杂志》2014年第3期806-809,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(No.81173404;No.81374031);上海自然基金项目(No.13ZR1442600)~~

摘　　要：非酒精性脂肪性肝病(NAFLD)发病率正在逐年上升。微小RNA(microRNA,miRNA)是一类长度为19-22个核苷酸的非编码小分子RNA,它参与基因转录水平后调控,具有调节细胞增殖、死亡、神经细胞分化、个体发育等重要的生物学功能。目前随着对miRNA研究的深入,发现miRNA与中医药防治NAFLD方面关系密切,文章从microRNA与NAFLD的中医病因、中医病机、中医证候及其防治等方面系统阐述了miRNA在中医药防治NAFLD中的应用。microRNA在NAFLD的病程中及发生发展过程中发挥着潜在的重要作用,将有更大的研究空间和发展前景。Nonalcoholic fatty liver disease （NAFLD） incidence rate is rising rapidly year by year. microRNA （miRNA） is a sort of small molecules RNA with length for 19-22 nucleotide of non coding. It involves in gene transcription level control, which can adjust cell proliferation, death, nerve cell differentiation, individual development and other important biological function. At present, with the further study on miRNA, increasing evidences shows that there is a close relationship between miRNA and prevention and treatment of NAFLD with traditional Chinese medicine. From some aspects, we shed light on application of miRNA in prevention and treatment of NAFLD with traditional Chinese medicine. MicroRNA plays an important role in the process of occurrence and development of NAFLD. And there will be more research space and development prospects for it in the future.

关 键 词：MICRORNA 中医药 防治 非酒精性脂肪性肝病 

分 类 号：R575.5[医药卫生—消化系统]