转录因子FOXP1在胃癌组织中的表达及意义  

Expression and Significance of Forkhead Box P1 in the Tissues of Gastric Cancer

作　　者：刘剑[1] 尚鑫[1] 沙素梅[1] 夏丽敏[1] 吴开春[1] 

机构地区：[1]第四军医大学西京消化病医院肿瘤生物学国家重点实验室,陕西西安710032

出　　处：《现代生物医学进展》2014年第5期814-818,共5页Progress in Modern Biomedicine

基　　金：国家重点基础研究发展计划"973项目"(2010CB529302);国家自然科学基金项目(81272652;81172290;91129723)

摘　　要：目的:检测FOXP1蛋白在胃癌组织及癌旁正常组织中的表达情况,并探讨其与胃癌患者病理参数及预后的关系。方法:采用免疫组织化学染色方法检测90例胃癌组织和相应癌旁正常组织中FOXP1的表达情况并进行评分,进一步统计分析FOXP1表达与胃癌患者临床病理参数以及预后的关系。结果:FOXP1在胃癌组织中的表达显著低于癌旁正常组织(P<0.01);对临床资料进行统计分析表明,在临床III期和IV期患者的胃癌组织中FOXP1的表达显著低于临床I期和II期的患者(P<0.05);FOXP1在低分化胃癌中的表达显著低于高、中分化胃癌(P<0.01);FOXP1表达阳性者术后总体生存率较表达阴性者高(P=0.145),中位生存期长。结论:FOXP1表达的减少可能参与了胃癌的发生发展,FOXP1在胃癌中可能扮演抑癌基因的角色,FOXP1可作为胃癌治疗的潜在靶点。Objective： To investigate the expression and clinical significance of Forkhead box PI（FOXP1） protein in gastric cancer tissues and adjacent non-tumor tissues. Methods： Immunohistochemistry was used to detect the expression of FOXP1 in 90 gastric cancer tissues and paired adjacent non-tumor tissues. Statistic analyses were explored to value its correlation with the clinicopathological characteristics and prognosis. Results： FOXP1 expression was significantly decreased in gastric cancer tissues compared with the corresponding adjacent non-tumor tissues （P〈0.01）. Further analysis about its correlation with the clinicopathological characteristics showed that FOXP1 expression was significantly lower in patients of clinical HI-IV stage than in I-II stage （P〈0.05）. The expression of FOXP1 was significantly lower in poorly differentiated gastric cancer than in moderately and well differentiated gastric cancer （P〈0.01）. Patients with FOXP1 positive expression had a better prognosis and longer median survival time than those with negative expression （P=0.145）. Conclusions： The decreased FOXP 1 expression may contribute to gastric cancer initiation and progression. FOXP 1 may play its role as a tumor suppressor in gastric cancer. FOXP1 is a potential therapeutic target in gastric cancer.

关 键 词：FOXP1蛋白 胃癌 免疫组织化学 抑癌基因 

分 类 号：R735.2[医药卫生—肿瘤]