PDCD4和DNMT1在卵巢上皮性癌中的表达及其临床意义  

Expression and Clinical Significance of PDCD4 and DNMT1 in Epithelial Ovarian Cancer

作　　者：杨秋丽[1] 王艳云 刘力山[1] 刘莉霞[3] 何秀萍[1] 

机构地区：[1]哈尔滨医科大学附属第一临床医院,黑龙江哈尔滨150001 [2]讷河市人民医院妇产科,黑龙江讷河161300 [3]牡丹江医学院红旗医院妇产科,黑龙江牡丹江157011

出　　处：《现代生物医学进展》2014年第5期873-877,共5页Progress in Modern Biomedicine

摘　　要：目的:检测PDCD4和DNMT1在正常卵巢组织、卵巢良性肿瘤组织、卵巢上皮性癌组织中的表达,并探讨其临床意义。方法:采用免疫组化法检测20例正常卵巢、25例卵巢良性肿瘤、40例卵巢上皮性癌组织中PDCD4和DNMT1的表达情况,分析其与卵巢上皮性癌临床病理参数之间的关系。结果:正常及良性卵巢组织中PDCD4的阳性表达率明显高于卵巢癌组(P<0.05),卵巢癌的FIGO分期越高,PDCD4的表达越低,卵巢癌的病理分化程度越低,PDCD4的表达也越低,PDCD4的表达与卵巢癌的组织类型、腹水、年龄、是否绝经无关。正常及良性卵巢组织中DNMT1的阳性表达率明显低于卵巢癌组(P<0.05),卵巢癌的病理分化程度越低,DNMT1的表达越高,但其与卵巢癌的FIGO分期、组织类型、腹水、年龄、是否绝经均无关。卵巢癌中DNMT1的与PDCD4的表达呈显著负相关(P<0.05)。结论:PDCD4和DNMT1在卵巢癌中的表达呈负相关,PDCD4的表达下调和DNMT1的表达上调可能在卵巢癌的发生及发展中起重要作用。Objective： To detect the expression of PDCD4 and DNMT1 in normal ovarian tissues, epithelial benign ovarian tumor tissues and ovarian epithelial carcinoma tissues, and investigate the clinical significance of PDCD4 and DNMT1 in ovarian epithelial carcinoma. Methods： The expressions of PDCD4 and DNMT1 in 20 Cases of normal ovarian tissues, 25 cases of epithelial benign ovarian tumor tissues, 40 cases of ovarian epithelial carcinoma tissues were detected by immunohistochemical method. Their relationship with the clinical pathological parameters of ovarian epithelial carcinoma were analyzed. Results： the positive expression rate of PDCD4 in normal and benign ovarian tissues were significantly higher than that in the ovarian cancer group （P〈0.05）.The higher FIGO stage of ovarian cancer was, the lower PDCD4 expression was; the lower opathological differentiation of varian cancer was ,the lower PDCD4 expression was. The PDCD4 expression was unrelated to the tissue types of ovarian cancer, ascites, age, whether menopause or not. The positiye expression rate of DNMT1 in normal and benign ovarian tissues were significantly higher than that in the ovarian cancer group （P〈0.05）.The lower pathological differentiation of ovarian cancer was, the higher DNMT1 expression was, but it was unrelated to the tissue types of ovarian cancer, ascites, age, whether menopause or not. The expression of DNMT1 and PDCD4 in ovarian cancer were significantly negative correlated （P〈0.05）. Conclusion： The expression of DNMT1 and PDCD4 in Ovarian cancer was negative correlation.PDCD4 downregulation and DNMT1 upregulation may play an important role in the occurrence and development of ovarian cancer.

关 键 词：卵巢癌 程序性细胞死亡因子4 DNA甲基转移酶1 表达 

分 类 号：R737.31[医药卫生—肿瘤]