原发性肝癌患者术后两种营养支持的疗效对比及对免疫功能的影响研究  

Comparison of Two Kinds of Nutritional Support on Efficacy and Immune Function and Impact for HCC Patients

作　　者：齐瑞兆[1] 李志伟[1] 张培瑞[1] 洪智贤[1] 余灵祥[1] 肖朝晖[1] 赵新[1] 张绍庚[1] 张克明[1] 

机构地区：[1]解放军第302医院肝胆外科一中心,北京100039

出　　处：《现代生物医学进展》2014年第5期888-891,共4页Progress in Modern Biomedicine

摘　　要：目的:研究原发性肝癌患者术后两种营养支持的疗效及对免疫功能的影响。方法:病例选自2010年10月至2012年11月在我院就诊治疗的90例经诊断为原发性肝癌并进行肝部分切除的患者,随机分为EN组和PN组,每组各45例,分别进行肠内和肠外营养支持治疗,观察术前及术后患者的营养状况、住院时间、肠道功能恢复时间、并发症情况及免疫功能的变化,经统计学处理,探讨两种不同营养支持疗法的临床疗效及对免疫功能的影响。结果:相对于PN组,EN组患者术后营养明显改善,胃肠道功能恢复相对较快,免疫功能明显提高,术后并发症明显减少,且P<0.05。差异具有统计学意义。结论:早期EN比PN更能改善肝癌病人术后肠道功能及营养状况,降低术后并发症,提高患者的免疫功能,有利于患者术后恢复。Objective： To study two kinds of nutritional support for primary liver cancer patients, and its effect on immune function. Methods： 90 cases of primary liver cancer with underwent liver resection in our hospital from October 2010 to November 2012 were selected, and were randomly divided into EN group and PN group （n = 45 patients）, which were treated by enteral and parenteral nutrition therapy, respectively. Nutritional status, length of stay, intestinal function recovery time, complications and changes in immune function of patients were observed before and after treatment. The clinical effects of two different nutritional support efficacy and their effects on immune function were analyzed statistically. Results： Compared to PN group, postoperative nutrition was significantly improved, the recovery of gastrointestinal function was relatively rapid, immune function was significantly improved, postoperative complications was reduced significantly in EN group （P 〈0.05, the difference had statistically significance）. Conclusion： In the Early period, EN is better for improving postoperative bowel function and nutritional status, reducing complications and improving the patient＇s immune function, helping patients recover than PN.

关 键 词：原发性肝癌 肠内营养 肠外营养 肝部分切除术 免疫功能 

分 类 号：R735.7[医药卫生—肿瘤]