牙周基础治疗对2型糖尿病伴牙周炎患者糖代谢及血清TNF-α的影响  

Effect of Periodental Non-surgical Treatment on Glycometabolism and the Level of Serum TNF-αin Type 2 Diabetes Mellitus with Chronic Periodontitis

作　　者：黄庆增 尤向阳 刘传通[3] 潘乙怀[3] 

机构地区：[1]洞头县人民医院口腔科,浙江温州325700 [2]洞头县人民医院内分泌科 [3]温州医科大学附属口腔医院

出　　处：《口腔医学研究》2014年第2期148-150,154,共4页Journal of Oral Science Research

基　　金：温州市科技计划项目(编号:Y20100015);洞头县科技计划项目(编号:S2012R27C)

摘　　要：目的:观察牙周基础治疗对2型糖尿病伴牙周炎(DMCP)患者牙周状况、糖代谢及血清肿瘤坏死因子-α(TNF-α)的影响,探讨其可能的影响机制。方法:选取DMCP患者和不伴有全身系统性疾病的慢性牙周炎(CP)患者各30例进行牙周基础治疗。在治疗前及治疗后1、3、6个月分别记录所有患者牙周临床指数:探诊深度(PD),附着丧失(AL)及探诊出血(BOP),并检测血清空腹血糖(FBG)、糖化血红蛋白(HbAlc)及TNF-α的水平。结果:DMCP组和CP组中PD、BOP和血清TNF-α水平在治疗后1个月、3个月和6个月时均显著降低(P<0.05),且CP组下降更显著(P<0.05)。AL在治疗后3个月开始显著降低(P<0.05),但两组间下降值无显著性差异。DMCP组血清FBG、HbAlc水平在治疗后3、6个月显著降低(P<0.05)。结论:牙周基础治疗能够明显改善牙周状况,并在一定程度上影响患者糖代谢水平。Objective： To observe the effect of periodental non--rsurgical treatment on periodontal condition, glyco- metabolism and the levei of serum TNF-α in type 2 diabetes mellitus with chronic periodontitis（DMCP）. Methods： 30 cases of type 2 diabetes patients with chronic periodontitis and 30 cases of chronic periodontitis（CP） patients without systemic disease were performed by periodental non--surgical treatment. The clinical periodontal indexes including probing depth（PD）, attachment loss（AL）, bleeding on probing（BOP） of every patient were recorded at pre--treatment, and after 1--month, 3--month and 6--month treatment, and fasting blood glucose（FBG）, glycosylated hemoglobin（HbAlc） and serum tumor necrosis factor（TNF-α） were measured at the same time. Results.. The level of PD, BOP and serum TNF-α was significantly reduced in both DMCP group and CP group after 1- month, 3--month and 6--month treatment （P〈0.05）, and CP group was more significantly reduced compared with DMCP group. The level of AL was significantly reduced after 3--month treatment （P〈0.05）, but there was no statistical diference in reducing levels between both groups. The FBG, HbAlc levels of DMCP were significantly reduced after 3--month and 6--month treatment（P〈0.05）. Conclusion.. Periodental non--surgical treatment can improve the periodontal condition and benefit the blood sugar level control of the patients.

关 键 词：牙周基础治疗 2型糖尿病 牙周炎 糖化血红蛋白 肿瘤坏死因子 

分 类 号：R781.4[医药卫生—口腔医学]