纳米TiO_2:C涂层对口腔常见细菌的抗菌效果观察  

Antibacterial Effect of TiO_2:C Composite Film Coating on Titanium

作　　者：麦理想[1] 张晟[2] 谢永建[1] 谢彬[1] 王大为[1] 张志光[3] 

机构地区：[1]中山大学光华口腔医学院附属口腔医院正畸科广东省口腔医学重点实验室,广东广州510055 [2]广东省口腔医院正畸科,广东广州510280 [3]中山大学光华口腔医学院//附属口腔医院颌面外科科广东省口腔医学重点实验室,广东广州510055

出　　处：《中山大学学报（医学科学版）》2014年第1期122-126,共5页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：中央高校基本科研业务费专项资金(11ykpy54)

摘　　要：【目的】考察纳米TiO2:C薄膜涂层的抗菌性能,为其在种植体周围炎防治中的应用奠定实验基础。【方法】制备TiO2及TiO2:C薄膜涂层,根据贴膜法,每个样品做3个平行样,每个样品重复3次实验,检测其对不同口腔常见细菌的抗菌效果;通过X射线能谱仪检测牙龈卟啉单胞菌胞膜的离子种类并计算离子含量,从而分析探讨纳米TiO2:C薄膜涂层的抗菌机理。【结果】本研究合成的纳米TiO2:C薄膜涂层厚度均匀,对口腔常见细菌20 min可见光催化抗菌率均达到90%以上,具有良好的抗菌效果。X射线能谱显示牙龈卟啉单胞菌Na离子、Ca离子含量随着光催化时间的延长而降低,而P元素变化趋势无规律。【结论】纳米TiO2:C薄膜涂层对口腔细菌有很强的抗菌效果,改善了基体材料的抗菌性能。纳米TiO2:C薄膜涂层的可见光催化抗菌机理之一可能为改变细胞膜的结构,影响细胞膜的通透性。[Objective] In this study, antibacterial effect of TiO2： C composite thin film was investigated aiming to lay foundation for the use of this film in prevention and treatment of peri-implantitis. [Methods] Scanning electron microscope （SEM） was used to study the morphology of this coating film and the nick-fastness of the coating was analyzed by an automatic coat adhesion tester. The antibacterial efficacy of the TiO2： C composite film was tested by film applicator coating method. Antibacterial mechanism of TiO2： C composite film was discussed by X-ray energy dispersion spectrum （XED）. [Results] More than 90% of bacterium were killed within 20 minutes which confirm fine antibacterial effect of the film. The results of XED showed that, under the visible light photochemical catalysis of TiO2： C thin film, constitution and permeability of P.gingivalis cellular membrane could be changed which result in functional change. [Conclusion] With outstanding antibacterial property, the TiO2：C composite thin film will be a potential coating material of micro-implant.

关 键 词：微型支抗种植体 纳米二氧化钛 抗菌效果 

分 类 号：R783.1[医药卫生—口腔医学]