年龄相关黄斑变性亚临床炎症机制的研究现状  

Current research status of the mechanism of age- related macular degeneration parainflammation

作　　者：刘绚丽[1] 李平华[1] 

机构地区：[1]重庆医科大学附属第一医院眼科,中国重庆市400016

出　　处：《国际眼科杂志》2014年第3期451-453,共3页International Eye Science

摘　　要：年龄相关性黄斑变性(age-related macular degeneration,AMD)是一个多因素多基因多过程介导的慢性退行性病变。亚临床炎症是组织结构对损害性应激或者异常功能做出的介于炎症和正常之间的状态,其生理功能是保存正常功能和稳态。本文旨在通过亚临床炎症为中心,探讨AMD各种致病机制的内在联系。在个体遗传基因不同易感性为基础上,危险因素直接或者间接通过氧自由基累积影响基因,导致视网膜神经层-色素表皮细胞-Bruch膜-脉络膜毛细血管(neuroretina-pigment epithelium-Bruch's membrane-choriocapillaris,NR-RPE-MB-CC)长期处于一种亚临床炎症状态,最终导致视网膜细胞凋亡或者脉络膜血管增生。Age -related macular degeneration （ AMD ） is a multifactorial - and polygenic - mediated chronic degenerative disease.Parainflammation is defined as a condition of tissue adaptive response to noxious stress or malfunction, it has features which are considered as intermediate between normal/basal and inflammatory/acute states.With the genetic predispositions, increased reactive oxygen species （ ROS ） generation cause the complement activation, placing the neuroretina-pigment epithelium-Bruch＆#39;s membrane-choriocapillaris （ NR-RPE-MB-CC ） in the chronic condition of parainflammation which mediate apoptosis and angiogenesis, leading to AMD.

关 键 词：年龄相关性黄斑变性 亚临床炎症 补体系统 基因 氧自由基 

分 类 号：R774.5[医药卫生—眼科]