托莫西汀联合脑电生物反馈治疗儿童注意缺陷多动障碍疗效观察  

Efficacy Evaluation of Atomoxetine and EEG Biofeedback Combination Therapy in Children with Attention Deficit Hyperactivity Disorder

作　　者：顾教伟[1] 王勇[1] 赵峰[1] 姜浩[1] 王大斌[1] 

机构地区：[1]湖北医药学院附属太和医院,湖北十堰442000

出　　处：《儿科药学杂志》2014年第3期15-17,共3页Journal of Pediatric Pharmacy

摘　　要：目的:研究托莫西汀联合脑电生物反馈治疗儿童注意缺陷多动障碍(ADHD)的疗效。方法:对46例ADHD患儿给予托莫西汀与脑电生物反馈治疗4个月,于治疗前后详细记录患儿注意力商数与反应控制商数中视觉、听觉商数以及进行Conners儿童行为量表父母问卷并进行评估。结果:与治疗前比较,观察组注意力商数与反应控制商数中视觉、听觉商数较治疗前明显升高,差异有统计学意义(P<0.05);Conners量表评分较治疗前均明显下降,差异有统计学意义(P<0.05)。与对照组比较,治疗后注意力商数与反应控制商数中视觉、听觉商数差异均无统计学意义(P>0.05);治疗后Conners量表评分在多动指数、学习问题、冲动-多动、品行问题等4个方面差异均无统计学意义(P>0.05),而在心身障碍、焦虑两个方面评分明显下降,差异有统计学意义(P<0.05)。结论:托莫西汀联合脑电生物反馈治疗ADHD可以更好的改善患儿的注意缺陷、多动和冲动等核心症状。Objective： To study the effect of atomoxetine and EEG biofeedback combination therapy in children with attention deficit hyperactivity disorder （ADHD）. Methods： Forty-six children with ADHD were treated with tomoxetine and EEG biofeedback for four months. The reports of audio-visual integration test （IVA-TP） , Conners parent rating scales and children behavior checklist parent questionnaire were used for assessing the efficacy. Results： In the observation group attention quotient and response control quotient were significantly increased after treatment ; the difference was statistically significant （ P〈0.05 ）. The Conners parent rating scales was significantly decreased compared with those before treatment ; the difference was statistically significant （ P〈0. 05 ）. Compared with the control group, after treatment the attention quotient and visual, auditory response control quotient were not significantly different （ P〉0.05 ）. After treatment, there were no differences in hyperactivity index, learning problems, hyperactivity and impulsive, behavior problems of Conners scale （P〉0.05）, but psychosomatic disorder and anxiety were decreased significantly; the differences were statistically significant （P 〈 0. 05 ）. Conclusions： Atomoxetine combined with EEG biofeedback can improve attention deficit hyperactivity and impulsivity of ADHD.

关 键 词：注意缺陷多动障碍 托莫西汀 脑电生物反馈 儿童 

分 类 号：R742.1[医药卫生—神经病学与精神病学]