食管癌患者放疗前后血清sIL-2R的研究  

The Study of sIL-2R in Esophageal Carcinoma Ratients Before and After Radiotherapy

作　　者：梁业民[1] 程玉峰[1] 刘秋良[1] 张伟[1] 靳传红[1] 

机构地区：[1]山东医科大学一附院肿瘤中心,济南250012

出　　处：《肿瘤防治研究》2001年第1期42-43,共2页Cancer Research on Prevention and Treatment

摘　　要：目的　探讨食管癌患者放疗前后血清 s IL- 2 R的变化及临床意义。方法　用双抗体夹心 ELISA法检测了 50例食管癌患者放疗前后血清 s IL- 2 R水平。结果　食管癌患者放疗前血清s IL- 2 R水平显著高于正常人 (P<0 .0 0 1 ) ,且随病情进展而升高。放疗后血清 s IL- 2 R水平较放疗前显著降低 (P<0 .0 1 )。存活二年的患者放疗结束时 ,血清 s IL - 2 R<80 0 u/ml与 80 0 u/ml两组有明显差异 (P<0 .0 1 )。结论　食管癌患者血清 s IL- 2 R明显增高 ,并与肿瘤进展 ,预后密切相关 ,可为肿瘤治疗疗效和判断预后的一个重要指标。Objective To study the clinical significance of the serum sIL\|2R level befor and after radiotherapy in the esophageal carcinoma.Methods In this study we used the methods of ELISA to test the serum sIL\|2R levels of 80 cases which including 50 cases of esophageal carcinoma and 20 cases of healthy controls.Results The serum sIL\|2R level in esophageal carcinoma patients was significantly higher than that of healthy controls (P<0.001).The serum levels of sIL\|2R were significantly reduced at the end of radiotherapy(P<0.01).The 2\|year survival rate was higher among those cases with<800u/ml sIL\|2R level than those with>800u/ml.Conclusion The serum sIL\|2 level may indicate clinical meaning in judging the therapeutic effect and prognosis.

关 键 词：食管癌 放射疗法 SIL-2R 免疫功能 

分 类 号：R735.1[医药卫生—肿瘤] R730.55[医药卫生—临床医学]