5-羟色胺1A受体C(-1019)G基因多态性与老年抑郁症和伴有抑郁症状的阿尔茨海默病的关联研究  

Association between the 5-HT1Areceptor gene C(-1019)G polymorphism and geriatric depression and Alzheimer′s disease with depressive symptoms

作　　者：饶冬萍[1] 陈建华[1] 温全球[1] 黄杏笑[1] 沐楠[1] 陈建平[1] 徐世超[1] 韩海英[1] 刘文滔[1] 

机构地区：[1]广州市脑科医院,510370

出　　处：《实用医学杂志》2014年第5期758-760,共3页The Journal of Practical Medicine

基　　金：广东省医学科研基金项目(编号:B2011275);广州市医药卫生科技项目(编号:201102A213180)

摘　　要：目的:探讨中国汉族人群中5-羟色胺(5-hydroxytryptamine,5-HT)1A受体C(-1019)G基因多态性与老年抑郁症和伴有抑郁症状的阿尔茨海默病(Alzheimer′s disease,AD)的关系。方法:采用病例对照研究方法,以106例老年抑郁症(老年抑郁症组)、72例伴有抑郁症状的AD患者(AD组)和150例正常老年人(正常对照组)为研究对象,用聚合酶链反应-限制性片段长度多态性技术检测5-HT1AC(-1019)G多态性。结果:老年抑郁症组5-HT1A(-1019)C/G基因型(39.6%)、G/G基因型频率(24.5%)、G等位基因频率(44.3%)均高于正常对照组(分别为35.3%、13.3%、31.0%),差异有统计学意义(χ2分别为7.954 9、9.515 7,均P<0.05)。伴有抑郁症状的AD组5-HT1A(-1019)G等位基因频率(41.0%)高于正常对照组(31.0%),差异有统计学意义(χ2=4.287 9,P<0.05),基因型分布频率差异无统计学意义(χ2=3.650 6,P>0.05)。老年抑郁症组5-HT1A(-1019)G等位基因及各基因型分布频率与AD组的差异均无统计学意义(χ2值分别为0.365 6、0.395 7,均P>0.05)。结论:5-HT1A受体C(-1019)G基因多态性可能在老年抑郁症及伴有抑郁症状的AD患者的发病中起一定作用,G等位基因可能是其风险因子之一。Objective To investigate the relationship between the 5-hydroxytryptamine （5-HT）1A receptor gene C （-1019）G polymorphism and geriatric depression and Alzheimer＇s disease （AD） with depressive symptoms in Han Chinese. Methods The case control study was used in the study among 106 patients with geriatric depression, 72 AD patients with depressive symptoms and 150 healthy old individuals in China. The C （-1019）G polymorphism of 5-HT1A was analyzed with the technique of polymerase chain reaction-restriction fragment length polymorphism. Results The frequencies of 5-HTIA genotype C/G （39.6%）, G/G（24.5%） and allele G （44.3%） in the patients with geriatric depression were significantly higher than those in the controls （respectively 35.3%, 13.3%, 31.0%, P 〈 0.05）. The frequencies of 5-HTIA G allele in the AD patients with depressive symptoms （41.0%） were significantly higher than those in the controls （31.0%, X2 = 4.2879, P 〈 0.05）. No significant difference in distribution of （5-HT）IA C （-1019） G polymorphism between the patients with geriatric depression and the AD patients with depressive symptoms was observed （P 〉 0.05）. Conclusion The 5-HTjA gene C （-1019）G polymorphism may be associated with geriatric depression and AD with depressive symptoms and （-1019）G allele may be a risk factor for them.

关 键 词：抑郁症 阿尔茨海默病 老年 5-羟色胺1A受体 基因多态性 

分 类 号：R749.4[医药卫生—神经病学与精神病学]