血管免疫母细胞性T细胞淋巴瘤患者EB病毒感染情况及其临床意义  

Retrospective analysis of EB virus infection in patients with angioimmunoblastic T-cell lymphoma and its clinical significance

作　　者：薛学敏[1] 高子芬[1] 王小燕[2] 谷从友[3] 李敏[1] 刘翠苓[1] 黄欣[1] 

机构地区：[1]北京大学基础医学院病理学系血液病理研究室,100191 [2]河南省人民医院病理科 [3]蚌埠医学院病理教研室

出　　处：《白血病．淋巴瘤》2014年第2期96-99,共4页Journal of Leukemia & Lymphoma

摘　　要：目的 探讨血管免疫母细胞性T细胞淋巴瘤患者的EB病毒感染情况及其临床病理学意义.方法 回顾性分析2008年1月至2011年12月经常规外检及会诊确诊的血管免疫母细胞性T细胞淋巴瘤62例,进行常规形态学和免疫学表型分析,采用原位杂交方法检测EB病毒编码小RNA（EBV-EBER）的表达情况,并随访患者.结果 62例血管免疫母细胞性T细胞淋巴瘤患者中,EBV-EBER阳性者26例（42％）.EBV-EBER表达与患者年龄大于60岁以及治疗反应密切相关（P=0.025、0.049）,而与患者的总体生存时间、临床B症状及Ann Arbor分期无关（均P＞0.05）.结论 血管免疫母细胞性T细胞淋巴瘤患者EB病毒感染不影响总体生存时间,但影响患者对治疗的反应.Objective To investigate the EB virus （EBV） infection and its clinical significance in angioimmunoblastic T-cell lymphoma（AITCL）.Methods 62 patients diagnosed as AITCL between 2008 Jan and 2011 Dec were retrospective analyzed.All cases were re-confirmed and classified with the histology and immunology according to 2008 WHO Classification.In situ hybridization of EBV encoded RNA （EBV-EBER） was performed.Clinical characteristics and follow-up data of patients were collected.Results 42 % （26/62） AITCL cases were EBER-positive.EBV infection was found to be significant correlation with age over 60 years and poor response to therapy （P =0.025,P =0.049,respectively）.However,EBV infection had no relationship with the overall survival,the presence of B symptom and the Ann Arbor stage.Conclusion In AITCL,EBV infection seems not to be associated with the overall survival,B symptom and Ann Arbor stage,but it may have impacts on theraputic response.

关 键 词：淋巴瘤 T细胞 血管免疫母细胞 EB病毒 EBER 预后 

分 类 号：R733.1[医药卫生—肿瘤]