肝病患者血硒水平与甲胎蛋白浓度的相关性研究  

Correlative Study on Blood Selenium Level and AFP Concentration in Patiensts with Liver Disease

作　　者：张启南[1] 李文广[1] 倪正平[1] 陆建华[1] 黄飞[1] 诸亚君[2] 余权 

机构地区：[1]江苏省启东肝癌研究所,江苏启东226200 [2]中国医学科学院肿瘤研究所,北京100000

出　　处：《广东微量元素科学》2000年第9期23-26,共4页Trace Elements Science

摘　　要：硒是人体不可缺少的一种微量元素 ,其水平的高低影响着机体的肿瘤免疫反应 ;甲胎蛋白是癌胚蛋白 ,其浓度的高低反映了肝脏损害的程度 (除胎儿期外 )。本文血硒水平与甲胎蛋白浓度相关性研究结果表明 ,两者呈负相关 (相关系数为 - 0 6 2 7) ,且血硒水平呈现慢乙肝 >肝硬化 >肝癌。提示硒对肝脏具有一定的潜在保护作用 ,补硒可以预防肝癌 ,在肝癌治疗中适量补硒 ,对增强患者免疫功能、延长生存期有着十分重要的临床意义。Selenium(Se) is an indispensable tract element in human body,whose concentration influence the tumo rimmunitive reaction.AFP is an carcinoma embryo protein,and its concentration(except in embryo phase)indicates the degree of liver injury.The results of correlative study on blood Se level and AFP concentration show a negative correlation between them.The correlative coefficient is -0 627.Moreover,the blood Se concentration of chronic B hepatitis patients is higher than that of cirrhosis and liver cancer.It suggests Se has a certain potential protective function for liver.The compensation of Se can prevent liver cancer.During the therapy of liver cancer,adding appropriate Se has a very important clinic significance on improving immunity and prolonging survival for sufferers with liver disease.

关 键 词：肝病 血硒 甲胎蛋白 负相关 浓度 肝癌 

分 类 号：R735.7[医药卫生—肿瘤]